At the onset of stationary phase, Bacillus subtilis secretes at least seven extracellular proteases of which subtilisin (aprE) and a neutral metalloprotease E (nprE) are the most abundant (6). Of the remaining five minor extracellular proteases, Epr (epr) contributes 2 to 4% to this pool (18). The expression of these enzymes is stringently regulated, as best exemplified by the aprE gene (23). H...

Este artigo é fruto da monografia intitulada Entre Colmeias & Quilombos, e visa se debruçar nos elementos afrocentrados afrorreferenciados presentes na obra The Gift/Black is King, multiartista Beyoncé. Na costura entre a Afrocentridade Antropologia, junto proposta metodológica de análise conteúdo, intenta compreendemos arte, principalmente partir das músicas o álbum, como locus tensionador...

Gram-positive bacteria use peptides as auto-inducing (AI) signals to regulate the production of extracellular enzymes (e.g., proteases). ComX is an AI peptide, mostly known for its role in the regulation of bacterial competence and surfactant production in Bacillus subtilis. These two traits are regulated accordingly to the bacterial population size, thus classifying ComX as a quorum sensing si...

BACKGROUND Age-related macular degeneration (AMD) causes the dysfunction of the retinal pigment epithelial (RPE) cells. In this study, we examined the effects of riluzole, a sustained activator of the TRAAK potassium channel, on human RPE (ARPE-19) cells in an oxidant-induced cell-injury model and elucidate the mechanism of riluzole on RPE cell apoptosis. METHODS The follow four groups of ARP...

PURPOSE The expression and alternative splicing of the four FGF receptor (FGFR) mRNAs are regulated in a developmental- and tissue-specific fashion. Capability of differentiation in vitro of the retinal pigment epithelial cell line ARPE-19 has been previously demonstrated. In this study, the hypothesis that FGF receptor gene expression and the alternative splicing of the FGFR1 mRNA is regulated...