To improve the efficacy of drug delivery, active targeted nanotechnology-based drug delivery systems are gaining considerable attention as they have the potential to reduce side effects, minimize toxicity, and improve efficacy of anticancer treatment. In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA...

In this paper we propose Block Device Layer with Automatic Parallelism Tuning (BDL-APT), a mechanism that maximizes the goodput of heterogeneous IP-based Storage Area Network (IP-SAN) protocols in long-fat networks. BDL-APT parallelizes data transfer using multiple IP-SAN sessions at a block device layer on an IP-SAN client, automatically optimizing the number of active IP-SAN sessions accordin...

Mucin 1 (MUC1) is an important molecular target for cancer treatment because it is overexpressed in most adenocarcinomas. In this study, a new MUC1-targeted drug delivery system was assembled using an aptamer (Apt) that could recognize MUC1 and a DNA tetrahedron (Td) that could carry doxorubicin (Dox) within its DNA structure. The complex thus formed (Apt-Td) had an average size of 12.38 nm and...

Amide proton transfer (APT) imaging is a novel MRI technique, in which the amide protons of endogenous proteins and peptides are irradiated to accomplish indirect detection using the bulk water signal. In this paper, the APT approach was added to a standard brain MRI protocol at 3T, and twelve patients with high-grade gliomas confirmed by histopathology were scanned. It is shown that all tumors...

BACKGROUND Antiphospholipid antibodies are associated with recurrent fetal loss, but the clinical relevance of antiprothrombin (aPT) antibodies remains controversial. This study was designed to evaluate the relationship of plasma concentrations of aPT antibodies (IgG, IgM, and IgA isotypes) and recurrent spontaneous abortion (RSA) not associated with antiphospholipid-antibody syndrome. METHOD...

BACKGROUND The optimal antiplatelet therapy (APT) treatment strategy after Coronary Artery Stenting (CAS) in non-cardiac surgery, such as total knee arthroplasty (TKA) or urgent TKA-related surgery remains unknown. METHODS We built a decision tree model to examine the mortality outcomes of two alternative strategies for APT after CAS use in the perioperative period namely, continuous use and ...

We propose a class of synthetic optical materials in which the refractive index satisfies n(−x) = −n∗(x). We term such systems antisymmetric parity-time (APT ) structures. Unlike PT -symmetric systems, which require balanced gain and loss, i.e., n(−x) = n∗(x), APT systems consist of balanced positiveand negative-index materials. Despite the seemingly PT -symmetric optical potential V (x) ≡ n(x)...

A decade ago, atom probe tomography (APT) was applied almost exclusively to the study of metals, since the study of materials with lower conductivities, such as semiconductors, was considered pragmatically to be very difficult. The advent of commercially-available laser-pulsed APT systems has since enabled the increasingly widespread application of APT to semiconductors, with particularly notab...

Stent thrombosis (ST) is a severe and feared complication of coronary stenting. Patients who have suffered from ST are usually treated according to the "one-size-fits-all" dosing regimen of aspirin and clopidogrel. Many ST patients show high on-treatment platelet reactivity (HPR) despite this antiplatelet therapy (APT). It has been shown that HPR is a risk factor for major adverse cardiac event...

Analysis of patterns in time (APT) is a method for gathering information about observable phenomena such thatprobabilities of temporalpatterns of events can be estimated empirically. If appropriate sampling strategies are employed, temporal patterns can be predicted from APT results. As an example of the fruitfulness of APT, it was discovered in a classroom observational study that elementary s...