Garlic is known as a potent spice and a medicinal herb with broad therapeutic properties ranging from antibacterial to anticancer and anticoagulant. Our previous studies have shown some immunoregulatory effects for aged garlic extract, suggesting a key role for 14-kD glycoprotein of garlic in shifting the cytokine pattern to T helper-1. In present study, we investigated the effect of 1, 2, and ...

OBJECTIVE Garlic is a plant has been used as a flavor, and anti-microbial and anti-diarrheal agent. Infectious bronchitis virus (IBV) is a coronavirus. The available vaccines against IBV cannot cover new variants. This study evaluated the inhibitory effects of garlic extract on IBV. MATERIALS AND METHODS The constituents of garlic extract were detected by gas chromatography. This study was do...

Hypotensive effect of garlic extract involving releasing of various prostaglandins is well documented. To further evaluate the prostaglandin-like activity of garlic extract, its effect has been demonstrated using isolated rat fundus strip and rat colon preparation. Garlic extract produced the effects on the isolated tissue similar to those of PGE. The use of this response as a bioassay for pros...

Study was designed to elucidate the mechanism of hypotensive effect of garlic extract in dogs. The antagonists for common endogenous hypotensive substances (histamine, Acetylcholine, 5 Hydroxy Tryptamine Kinins and prostaglandins) were tried to confirm or exclude the possibility that garlic extract either acts like or causes release of any one of these endogenous hypotensive agents. The results...

Article history: Received: 31 Jan 2012 Accepted: 19 Apr 2012 Available online: 29 Oct 2012 ZJRMS 2013; 15(6): 43-49 Background: As relatively avirulent enteric bacteria, enterococci usually cause infections in immune-compromised patients. The antimicrobial treatment, however, is quite challenging, since enterococci are intrinsically resistant to many antibiotics. Objective of the present study...

Streptolysin O (SLO) is a potent cytolytic toxin produced by almost all strains of group A streptococci and is considered an important virulence factor for this organism. In this study we investigated the effect of allicin and aqueous garlic extracts on the haemolytic activity of SLO. All tested materials potentially inhibited the SLO haemolytic activity. Allicin neutralized SLO in a dose- and ...

Effect of aqueous extract of garlic on hepatic injury due to lead-induced oxidative stress in experimental rats has been investigated. Lead acetate (LA) at a dose of 15 mg/kg body wt was administered ip to rats for 7 consecutive days to induce hepatic injury. Freshly prepared aqueous garlic extract (AGE) at a dose of 50 mg/kg body wt was fed orally to rats 1 h before LA treatment for similar pe...

Protein glycation involves formation of early (Amadori) and late advanced glycation endproducts (AGEs) together with free radicals via autoxidation of glucose and Amadori products. Glycation and increased free radical activity underlie the pathogenesis of diabetic complications. This study investigated whether aged garlic has more potent antiglycation and antioxidant properties compared to fres...

Recent studies have shown that deoxygenated human red blood cells (RBCs) converted garlic-derived polysulfides into hydrogen sulfide, which in turn produced vasorelaxation in aortic ring preparations. The vasoactivity was proposed to occur via glucose- and thiol-dependent acellular reactions. In the present study, we investigated the interaction of garlic extracts with human deoxygenated RBCs a...