Patients with schizophrenia often manifest deficits in behavioral flexibility. Non-competitive NMDA receptor antagonists such as MK-801 induce schizophrenia-like symptoms in rodents, including cognitive functions. Despite work exploring flexibility has been done employing behavioral paradigms with simple stimuli, much less is known about what kinds of flexibility are affected in an MK-801 model...

This paper presents the design of a new version of the Arena operating system targeted at real-time applications. Arena is a run-time operating system for parallel applications. The main principle of Arena is to provide predictable and controllable resource management. This is achieved by placing resource management at the user level of the system, thereby allowing any degree of application inf...

This meeting report presents the cutting-edge research that is developing around the waterflea Daphnia, an emerging model system in environmental genomics. Daphnia has been a model species in ecology, toxicology and evolution for many years and is supported by a large community of ecologists, evolutionary biologists and ecotoxicologists. Thanks to new advances in genomics and transciptomics and...

We model limited attention as incomplete usage of publicly available information. Informed players decide whether or not to disclose to observers who sometimes neglect either disclosed signals or the implications of non-disclosure. These observers may choose ex ante how to allocate their limited attention. In equilibrium observers are unrealistically optimistic, disclosure is incomplete, neglec...

In this paper we present an agent-based evacuation model which may be used to support private sector organizations with capabilities-based planning efforts surrounding likely terrorist attack scenarios. The model is distinguished by its explicit consideration of individuals with disabilities in respect to the characteristics influencing their ability to negotiate surroundings. The virtual envir...

globalisation has given birth to medical tourism. health and medical tourism are the fastest growing seg­ments in not only developed nations but in developing countries too. india has become a hot des­tina­tion, as the indian medical standards match up to the highly prescribed international standards at a very low cost. however, it is an unmixed blessing; along with advantages, it has many unin...

Prorenin, the precursor of renin, exists in circulating blood at concentrations that are 5 to 10 higher than those of renin. For many years, prorenin was considered to be an inactive form of renin with no physiological role. Then, in the mid-80s of the last century, Luetscher et al reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects.1 Subsequent s...

The purpose of this study was to reduce patient waiting times, improve system throughput and improve resources utilization in radiology department. A discrete event simulation model was developed using Arena simulation software to investigate different alternatives to improve the overall system delivery based on adding resource scenarios due to the linkage between patient waiting times and reso...

In this paper we present a simulation model coupled with a search algorithm to find the optimal initial setting of the process mean and the optimal production run (cycle length). The simulation package SIMAN/ARENA is used to simulate the considered process. One of the features of SIMAN/ARENA is that it supports Microsoft Visual Basic for Application (VBA) which is used to code the search algori...