Previous work from this laboratory (1, 2) has demonstrated that the vasopressin from beef posterior pituitary lobes, after partial purification by the procedure of Kamm et al. (3), can be obtained in a high degree of purity by means of countercurrent distribution with the system 0.09 M p-toluenesulfonic acid-n-butyl alcohol. Although no detectable difference was observed in the physical propert...

1. Urinary excretion of digoxin-like immunoreactive factor and arginine-vasopressin and other parameters related to salt and water metabolism were studied in hyper- and hypo-thyroid rats after different tests. 2. Urinary excretion of arginine-vasopressin was increased in hyperthyroid and reduced in hypothyroid rats with respect to controls, in response to water deprivation or a hypertonic salin...

One of the mechanisms of glucocorticoid-induced hypertension has been thought to be the enhancement of vascular responsiveness to vasoconstrictors. In this regard, the effects of glucocorticoids on inositol trisphosphate production in vascular smooth muscle cells were studied. Angiotensin II and arginine vasopressin transiently increased inositol trisphosphate formation in a dose-dependent mann...

OBJECTIVE Selective vasopressin V(1A) receptor agonists may have advantages over arginine vasopressin in the treatment of septic shock. We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model. DESIGN Randomized animal study. SETTING University hospital an...

Vasopressin and oxytocin are the only hormones known to be secreted by the neurohypophysis in humans. Human vasopressin is called arginine vasopressin (AVP) to distinguish it from lysine vasopressin in pigs. It is also called antidiuretic hormone (ADH), which reflects its major physiologic action. These hormones are nonapeptides (nine amino acids) with similar primary structures but very differ...

1. Arginine vasopressin was infused into seven healthy young male volunteers at 12-5 and 25 units/min for 1 h at each dose. Plasma renin activity fell sharply and progressively in each subject. The mean fall was 47% and 66% of the initial value at the end of the lower and higher rates of arginine vasopressin infusion respectively; over 70% of the observed fall in plasma renin activity occurred ...