Mast cell (MC) degranulation is the foundation of the acute phase of allergic rhinitis (AR). Previously, downregulation of GATA binding protein 3 (GATA-3) was shown to suppress MC activation in an AR mouse model. Binding of microRNA-135a (miR-135a) to GATA-3 was also observed, and overexpression of this miRNA decreased GATA-3 mRNA and protein expression. However, the effects of miR-135a on MCs ...

"Click chemistry" was explored to synthesize two series of 2-(1,2,3-triazolyl)adenosine derivatives (1-14). Binding affinity at the human A(1), A(2A), and A(3)ARs (adenosine receptors) and relative efficacy at the A(3)AR were determined. Some triazol-1-yl analogues showed A(3)AR affinity in the low nanomolar range, a high ratio of A(3)/A(2A) selectivity, and a moderate-to-high A(3)/A(1) ratio. ...

PURPOSE The purpose of this study was to investigate the expression of autophagy-related proteins in relation to androgen receptor (AR) status in estrogen receptor (ER)-negative breast cancers. METHODS We extracted 334 ER-negative breast cancer samples to construct tissue microarrays (TMAs), which were immunohistochemically stained for autophagy-related proteins (beclin-1, LC3A, LC3B, p62) an...

tumor necrosis factor alpha-inducible protein 3 (tnfaip3) gene polymorphisms have been reported to be associated with the susceptibility to several immune-related diseases. here we investigated the effect of tnfaip3 gene polymorphisms on the risk of allergic rhinitis (ar) in a chinese han population. the case-control study included 540 ar patients and 524 healthy controls. genotyping for tnfaip...

BACKGROUND Myocardial contractile response to beta1- and beta2-adrenergic receptor (AR) stimulation is severely impaired in chronic heart failure, in which G(i) signaling and the ratio of beta2/beta1 are often increased. Because beta2-AR but not beta1-AR couples to G(s) and G(i) with the G(i) coupling negating the G(s)-mediated contractile response, we determined whether the heart failure-assoc...

Background—Myocardial contractile response to 1and 2-adrenergic receptor (AR) stimulation is severely impaired in chronic heart failure, in which Gi signaling and the ratio of 2/ 1 are often increased. Because 2-AR but not 1-AR couples to Gs and Gi with the Gi coupling negating the Gs-mediated contractile response, we determined whether the heart failure–associated augmentation of Gi signaling ...

the flow of fluids in annular conduits has been studied for over sixty years, however the resulted data are very scattered. in this paper the problem is analytically solved, starting out with navier-stokes equations. a computer solution is used to determine the shape of velocity profiles, the discharge and the friction factor in a large number of concentric and eccentric annular conduits. the e...

objectives this study aimed to examine the relationship between patients’ anthropometric characteristics and depth of spinal needle insertion to the subarachnoid cavity. patients and methods 385 patients with asa class i – ii, aged 18 - 65 years and undergoing elective surgery of the lower abdomen and extremities under spinal anesthesia, were selected for this cross-sectional study. the patient...