Type 1 diabetes mellitus (T1DM) lacks insulin secretion due to autoimmune deficiency of pancreatic β-cells. Protecting islets and enhancing has been therapeutic approaches. Mannogalactoglucan is the main type polysaccharide from natural mushroom, which potential medicinal prospects. Nevertheless, antidiabetic property mannogalactoglucan in T1DM not fully elucidated. In this study, we obtained <...