The antiarrhythmic activity of bis-alkoxyphenyltriazaalkanes 1 and bis-alkoxyphenyldiazaalkanes 2 was analyzed in a model reperfusion arrhythmia rats. It found that the key requirements for compounds this are use 2,3,4 trimethoxyphenyl aromatic pharmacophores presence central nitrogen atom linker. most active were ALM-802 (trihydrochloride N –(2,3,4-trimethoxybenzyl)-N – {2-[(2,3,4-trimethoxybe...

Abstract Purpose of review This study aims to describe the pathophysiology pregnancy in pulmonary hypertension (PH) and recent literature on maternal fetal outcomes. Recent findings There is an increasing number pregnant women with PH. Maternal mortality arterial (PAH) ranges from 9 25%, most commonly heart failure arrythmias. The highest risk death peri-partum post-partum. Fetal/neonatal morbi...

Abstract Background: Brugada Syndrome (BS) is an inherited ion channelopathy characterized by an electrocardiographic (ECG) pattern of a coved type ST segment elevation in right precordial leads with or without right bundle branch block. Case Presentation: A 23-year old male presented with right lower quadrant abdominal pain. Further evaluation revealed a diagnosis of acute appendicitis. The ...

Interest in inherited cardiovascular conditions (ICCs) is fueled by resources devoted to its diagnosis, management, and research. The rapid advancement of DNA genomic sequencing deepens our understanding ICCs. ICC landscape empowers the development diagnostic guidelines discovery potential therapeutic targets promises novel therapeutics, especially precision cardiology. Therefore, it essential ...

Abstract Funding Acknowledgements Type of funding sources: None. Background Late gadolinium enhancement (LGE) has been proposed as an independent predictor ventricular arrhythmias. Purpose The purpose this study was to assess if myocardial scar characterization could enhance the risk stratification for life-threatening arrhythmias and sudden cardiac death (SCD). Methods We included patients wit...

Methods 145 consecutive opTOF >12 years old (mean 24±10 years) were evaluated by ECG 24-hour ambulatory monitoring, MR exam, echocardiography, cardiopulmonary exercise test and Amino-Terminal pro-Brain Natriuretc Peptide (NT-proBNP) blood assay. Clinical adverse events and MAA (atrial fibrillation, flutter, or atrial tachycardia) were recorded. RA dimension was assessed by summing the RA diamet...