BACKGROUND/AIMS Renal ischemia/reperfusion injury (IRI) is a very common clinical event and usually leads to ischemic acute renal failure (ARF). In the present study, we investigated the protective role of vitamin C in renal function and renal arterial relaxation following ischemic injury. METHODS IRI model in mice was used. Various biochemical parameters including nitric oxide (NO), reduced ...

The majority of arterial pseudoaneurysms treated in our department vascular surgery are consequences catheter-associated medical procedures and located the groin region. Clinical signs, combined with recent history a percutaneous intervention, ensure quick diagnosis therapy. However, can develop after any artery body is injured. No consensus on therapeutic strategy achieved because rare nature ...

BACKGROUND Impaired endothelial regeneration contributes to arterial lesion formation. Endostatin is a specific inhibitor of endothelial cell growth and induces endothelial cell apoptosis. We examined the effect of endostatin overexpression on reendothelialization and neointima formation in a mouse model of arterial injury. METHODS AND RESULTS Mice underwent femoral arterial denudation and re...

OBJECTIVES We examined the relative contributions of inflammation and arterial injury to neointimal formation in a porcine coronary overstretch restenosis model. BACKGROUND Previous studies established that stents cause neointimal proliferation proportional to injury. Although inflammation has been postulated to be a major contributor to restenosis after angioplasty, there is a paucity of dat...

BACKGROUND The effect of balloon injury on the arterial signal transduction pathway has not been examined. In vitro studies show that extracellular signal-regulated kinases (ERKs) and c-Jun NH2-terminal kinases (JNKs), belonging to the mitogen-activated protein kinase (MAPK) family, play a critical role in the activation of transcription factor activator protein-1 (AP-1) and cell proliferation ...