Arthrogryposis-renal tubular dysfunction-cholestasis syndrome (MIM No. 208085) is a rare multisystem disorder involving the liver, kidney, skin, and central nervous and musculoskeletal systems. The syndrome is an autosomal-recessive trait, associated with germ-line mutations in the VPS33B gene. We report an Iranian boy of consanguineous cousin parents who had congenital deformities of the upper...

Seven pectoralis major transfers in children suffering from bilateral paralysis of elbow flexion due to arthrogryposis or to trauma are reported. A technique is described in which the muscle is mobilised from the clavicle to allow the tendon of insertion to be attached to the biceps tendon at the elbow. The biceps tendon was found to be present and could be mobilised forwards in all the arthrog...

Disease name: Arthrogryposis multiplex congenita ICD 10: Q74.32 Synonyms: Arthrogryposis, Amyoplasia Congenita, Congenital Arthromyodysplasia, GuérinStern syndrome, Myodystrophia Fetalis Deformans AMC is the clinical description of a congenital syndrome with an estimated incidence of 1:3000-10,000 [25,30,38]. Already within the uterus, the movement frequency of the foetus is reduced due to mult...

This special issue of Journal of Children’s Orthopaedics includes seven papers on arthrogryposis multiplex congenita (AMC). Arthrogryposis is derived from the Greek words arthro (joint) and gryposis (crooked). The papers are based on lectures presented during the 31st Annual Meeting of the European Paediatric Orthopaedic Society (EPOS) held in Helsinki, April 18th–21st 2012, where EPOS Educatio...