Current treatment modalities for musculoskeletal injuries due to disease or trauma often implement the use of tissue grafts, cell transplantations, and artificial scaffolding. These approaches may be augmented with the use of specific biological factors, which accelerate healthy tissue regeneration. Unfortunately, the short half-life and inherent instability of proteins requires the delivery of...

Impact of small rodents on mountain forest regeneration was studied in National Nature Reserve in the Beskydy Mountains (Czech Republic). A considerable amount of bark damage was found on young trees (20%) in spring after the peak abundance of field voles (Microtus agrestis) in combination with long winter with heavy snowfall. In contrast, little damage to young trees was noted under high densi...

SUMMARY The ability of certain organisms to completely regenerate lost limbs is a fascinating process, far from solved. Despite the extraordinary published efforts during the past centuries of scientists performing amputations, transplantations and molecular experiments, no mechanistic model exists yet that can completely explain patterning during the limb regeneration process. The lack of a ce...

The present work was performed in the framework of the ESPRIT-project "INTER" aimed at the development of an "intelligent" artificial interface between the living nerve system and electronic devices. The design, the fabrication, and the characterisation of regeneration-type microelectrode arrays for in vivo recording of nerve signals is described here. The impedance of the microelectrodes could...

We present a method for constructing electronic circuits that uses analogues of biological multi-cellular development, genetic regulatory networks, and transcription and translation processes to build circuits. We show how small circuits may be evolved and how they may be reused to build larger circuits. We also demonstrate that the artificial ‘organisms’ are capable of regeneration so that cir...