Acid-sensing ion channels (ASICs) are neuronal non-voltage-gated cation channels that are activated when extracellular pH falls. They contribute to sensory function and nociception in the peripheral nervous system, and in the brain they contribute to synaptic plasticity and fear responses. Some of the physiologic consequences of disrupting ASIC genes in mice suggested that ASIC channels might m...

Rationale: Acid-sensing ion channels (ASICs) are Na channels that are activated by acidic pH. Their expression in cardiac afferents and remarkable sensitivity to small pH changes has made them leading candidates to sense cardiac ischemia. Objective: Four genes encode six different ASIC subunits, however it is not yet clear which of the ASIC subunits contribute to the composition of ASICs in car...

Introduction: A radiation hardened by design (RHBD) mixed-signal application specific integrated circuit (ASIC) has been designed for a thermopile readout for operation in the harsh Jovian orbital environment. The multi-channel digitizer (MCD) ASIC (shown in Figure 1) includes 18 low noise amplifier channels which have tunable gain/filtering coefficients, a 16-bit sigma-delta analog-digital con...

One aim of the RD27 project is to perform design and R&D work leading to a first level muon trigger for an experiment at the Large Hadron Collider (LHC) at CERN. This paper describes the design, implementation and testing of an ASIC for a trigger demonstrator system. The trigger system is implemented using a set of seven chambers. The low momentum trigger requires hits in three out of the four ...

Cryptographic hash functions have wide applications including password hashing, pricing functions for spam and denial-of-service countermeasures and proof of work in cryptocurrencies. Recent progress on ASIC (Application Specific Integrated Circuit) hash engines raise concerns about the security of the above applications. This leads to a growing interest in ASIC resistant hash function and ASIC...

In the vestibular system, the electrical discharge of the afferent neurons has been found to be highly sensitive to external pH changes, and acid-sensing ionic-channels (ASIC) have been found to be functionally expressed in afferent neurons. No previous attempt to assay the ASIC function in vestibular afferent neurons has been done. In our work we studied the electrical discharge of the afferen...

Recent studies suggest that certain acid-sensing ion channels (ASIC) are expressed in vascular smooth muscle cells (VSMCs) and are required for VSMC functions. However, electrophysiological evidence of ASIC channels in VSMCs is lacking. The purpose of this study was to test the hypothesis that isolated cerebral artery VSMCs express ASIC-like channels. To address this hypothesis, we used RT-PCR,...

Dissipation in the clock tree and state elements of ASIC designs is often a significant fraction of total energy consumption. We propose a methodology for recovering most of this energy by using a novel energy recovering flip-flop and a novel single-phase resonant clock generator. As our state element has near-zero energy consumption when the input data is not switching, it provides the savings...

This paper describes the methodology employed by the IBM Microelectronics Division for the design of its Blue Logic applicationspecific integrated circuits (ASICs) and system-on-a-chip (SoC) designs. This methodology is used by both IBM ASIC and SoC designers, as well as OEM customers. A key focus of the IBM ASIC/SoC methodology, outlined in the first section of this paper, is the first-time-ri...

Object tracking algorithms, when it comes to implementing it on hardware ASIC, it becomes difficult task, due to certain limitations in hardware. This paper shows how mean-shift algorithm is implemented in HDL along with the description of ports and interfaces. Keywords— Object tracking, complexity in hardware ASIC, Mean Shift algorithm, Histogram, Bhattacharya coefficient