The aim of the present study was to investigate the toxicological effects of moxifloxacin in mice to determine the toxicological implications. Forty mice of both sexes were divided into four groups of 10 mice each, designated as A, B, C and D. Group A served as the control and received 2 ml of distilled water, while Groups B, C and D were orally administered 12.5, 25 and 50 mg/kg body weight of...

BACKGROUND/AIMS Liver biopsy is considered a gold standard for fibrosis staging, but it has a high risk of morbidity. Therefore, there is an interest in developing noninvasive markers for the prediction of liver fibrosis stages. METHODS Hyaluronic acid, ferritin, N-acetyl-β-D-glucosaminidase, β-glucuronidase, glucosamine, aspartate transaminase, and alanine transaminase were assayed in 210 in...

OBJECTIVES We aimed to compare serum levels of interleukin-6, visfatin, and hyaluronic acid in chronic hepatitis C Egyptian patients who received standard of care (SOC) therapy for chronic hepatitis C virus (HCV) consisting of pegylated interferon (PEG-IFN) and ribavirin (RBV) and in those who received SOC with vitamin D (vit D) for 48 weeks in HCV genotype 4a subjects. DESIGN AND METHODS One...

The isolated aspartate/glutamate carrier and oxoglutarate carrier from mitochondria were coreconstituted into phospholipid vesicles. Reconstitution of the functionally active carrier proteins with high protein/lipid ratios was achieved by detergent removal on hydrophobic ion-exchange columns. A simplified version of the mitochondrial malate/aspartate shuttle was constructed by inclusion of glut...

Background: Red fox (Vulpes vulpes) is a pervasive carnivore species across most of Eurasia and parts North Africa. The current study was aimed to evaluate baseline values for selected haematological biochemical variables red in Ladakh, India. Methods: Blood samples were collected from female with drug combination Xylazine Ketamine. Selected assessed Result: total leucocytic count found as 6.37...

An overall 176% increase in enzyme activity followed byS ephadex G-25 (fine) whole urine fractionation and a highly significant (P L,001) partial inhibition by earlier Sephadex fractions and maximum inhibition by earlier Sephadex fractions and maximum inhibition of enzyme by fraction 7 have suggested the presence of both high and low molecular weight urinary inhibitors of aspartate-transaminase...

Aspartate aminotransferase (L-aspartate: 2-oxoglutarate aminotransferase, EC 2.6.1.1, glutamic-oxalacetic transaminase, GOT) comprises two isoenzymes. One is anionic and is associated principally with the soluble fraction of the cytoplasm, the other is cationic and is associated with the mitochondria [4]. A sensitive semi quantitative assay has been developed for cationic aspartate aminotransfe...

Glutamate dehydrogenase decreases the distribution COefficient of glutamate oxalacetate transaminase in Sephadex G-ZOO. This is consistent with previous results which suggested that a complex is formed between these two enzymes. These gel filtration as well as kinetic experiments suggest that transaminase can react with monomeric but not polymer forms of glutamate dehydrogenase. When the levels...

The hepato-protective effect of Telfaria occidentalis leaves supplementation on paracetamol induced liver toxicity in wistar rats was investigated. A total forty Wistar (female and male) weighing between 150-250g were selected for the study. animals randomly divided into four groups five each. Animals group 1 2 received standard chow only while 3 4 5% 10% T. their feed respectively six weeks. G...