The integrity of the sperm genome and epigenome are critical for normal embryonic development. The advent of assisted reproductive technology has led to an increased understanding of the role of sperm in fertilization and embryogenesis. During fertilization, the sperm transmits not only nuclear DNA to the oocyte but also activation factor, centrosomes, and a host of messenger RNA and microRNAs....

In this paper we present a method to generate optimal stimulation pattern for walker-assisted paraplegic walking using FES systems. To determine the stimulation patterns, a musculoskeletal model of walker-assisted FES-supported paraplegic walking is introduced. The optimal stimulation patterns are determined through minimizing the trajectory tracking error of the lower body and mechanical energ...

Abstract Sulfidic mining waste rock is a side stream from the industry with potential environmental burden. Alkali activation promising method for transforming into construction materials. However, low reactivity of minerals can be sizeable challenge in alkali activation. In present study, was enhanced by mechanochemical treatment LiCl-containing grinding aid. X-ray diffraction (XRD) and diffus...

the canola drying process was investigated using three laboratory scale dryers connected to a computer which continuously recorded the drying processes of each unit. a completely randomized design (crd) with three replications was used for the statistical analysis. the effect of temperature (40°, 50°, 60°c) and air velocity (1, 2 m/s) on the drying kinetics of a monolayer were studied. the effe...

objective: to evaluate the efficacy of in vitro sperm activation (isa) using non-liquefied versus liquefied asthenozoospermic semen samples for improvement of sperm parameters. materials and methods: fifty six oligoasthenozoospermic (oa) patients (age range: 22-44 years; mean: 32.089 years) were enrolled in this study. oa patients were classified according to type of infertility. also, duration...

thermal rearrangement of 7,7-dichloro-[a,c]-dibenzo-[4,1,0]-bicycloheptane (1) to 5,6-dichloro-5hdibenzo-[a,c]-cycloheptene (2) was studied in the solid phase and in solvents with different polarities. thefirst-order constants at various temperatures for the rearrangement process were evaluated from theabsorption time data. the activation parameters for this rearrangement were obtained from the...

In contrast to the majority of O2-activating enzymes, which depend on an organic cofactor or a metal ion for catalysis, a particular group of structurally unrelated oxygenases is functional without any cofactor. In this study, we characterized the mechanism of O2 activation in the reaction pathway of a cofactor-independent dioxygenase with an α/β-hydrolase fold, which catalyzes the oxygenolytic...

The possibility of tunable regioselective activation of a dinitrile towards nucleophilic attack was demonstrated. For that, a sulfo-arylhydrazone unit was introduced into malononitrile and the thus formed intramolecular hydrogen bond systems assisted specific nucleophilic attacks to the cyano moieties leading to a variety of amidines, carboxamides and iminoesters depending on the nucleophiles a...