objective(s): adeno-associated virus type 2 (aav2) vectors are widely used for both experimental and clinical gene therapy. a recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. in this study, a fast and simple method is presented to generate aav2 vector helper plasmids encodin...

the binding of drugs by plasma proteins is an important phenomenon, because it influences the size of the free fraction of the drugs in plasma. in this study the influence of dipyridamole (dp) on the protein binding of propranolol (pl) and pl on the protein binding of dp were studied alone and in the presence of nicotine (nc).        the equilibrium dialysis was employed for protein binding stu...

background and objective: obesity is an independent risk factor for cardiovascular diseases and diabetes. the abnormalities involved may be mediated by increased secretions of inflammatory proteins called adipocytokines by the adipose tissue. thus, monitoring adipocytokines during weight loss could be helpful in progress evaluation of weight reduction programs. since high-protein diets are cons...

cirrhosis is the consequence of chronic liver disease. deleterious effects of oxidative stress on hepatocytes may be reflected in the erythrocyte membrane. naltrexone (ntx) has been shown to attenuate hepatocellular injury in fibrotic animal models. the aim of this study was to investigate the progressive effect of ccl 4 on the liver and whether the improvement of liver cirrhosis can be monitor...

Objective(s): The purpose of this study was investigation of the protein corona formation on the surface of zwitterionic nanoparticles when they exposed to bio-fluid like human plasma.Methods: Silica nanoparticles with zwitterionic surface coating, cysteine and sulfobetaine were employed as zwitterionic ligands, were synthesized and characterized in terms of physicochemical properties. To...

introduction: mcp (membrane cofactor protein or cd46) is a complement regulatory proteins (crps), which is present in most of body cell membranes (except erythrocytes), and also in most biologycal body fliuds. due to the important role of this protein in the complement system, specially in fertility, the aim of this study was to determine and isolate this protein in human seminal plasma. materi...