BACKGROUND The incidence of perioperative myocardial infarction (PMI) globally is known to be around 2 to 3% and can prolong hospitalization, increased morbidity and mortality. Little is known about the pathophysiology and risk factors for PMI. We investigate the presence of elevated novel cardiac markers and preoperative coronary artery plaque through contemporary laboratory techniques to dete...

Abstract. Recent studies demonstrate a large number of non-lipid modifiable effects statins in various diseases. However, although atherogenic dyslipidemia is common feature peritoneal dialysis (PD) patients, use supported by limited data and there general lack research on their pleiotropic this patients’ cohort. The present study aimed to evaluate the possible atorvastatin PD patients.
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INTRODUCTION To investigate the hypothesis that atorvastatin decreases blood pressure (BP) values and improves endothelial function assessed by flow-mediated dilation (FMD) in normolipidaemic hypertensive patients. MATERIAL AND METHODS Fifty-six hypertensive patients were randomized in a 2 : 1 proportion to atorvastatin (80 mg/day/3 months; group A; n = 39) or previous standard anti-hypertens...

An accurate and reproducible liquid chromatographic assay method was developed and validated for the determination of Atorvastatin and Fenofibrate in capsule formulation. Water (pH 4.0) and acetonitrile (20:80, v/v) was used for reversephase liquid chromatography at detection wavelength 254 nm to determine the contents of Atorvastatin and Fenofibrate in combination capsule dosage form. The meth...

Background and Objectives: Lipoprotein-a potentially represents a useful tool for risk stratification in cardiovascular accidents.  The aim of this study was to evaluate the atorvastatin effect on serum lipid profile & lipoprotein A. Material & Methods: In 2009, 405 patients with acute coronary syndrome randomly were divided into 2 groups, taking 20 & 40 mg atorvastatin daily for 3 months. Lip...

BACKGROUND The aim of this study was to investigate the therapeutic effect of abnormal Savda Munziq (ASMq) on the development of degenerative atherosclerotic aortic valve disease and its underlying mechanisms. MATERIAL AND METHODS We randomly divided 80 rabbits into 4 groups: a normal control group (group N, n=20); a high-fat diet group (group HC, n=20); a high-fat diet and Atorvastatin calcium...

Atorvastatin calcium, a lipid-lowering drug, is much less bioavailable because of reduced solubility in acidic media. Multiple-unit floating microcapsules of Atorvastatin calcium (ATC) were developed to expand the gastric residence time of the drug, as ATC has maximum rate of absorption in the upper GI tract. Floating microcapsules were prepared by Emulsion-solvent evaporation technique through...

Quantitative characterization of atherosclerotic plaque composition with standard histopathological methods remains limited to sectioned plaques. Raman spectroscopy enables nondestructive quantification of atherosclerotic plaque composition. We used Raman spectroscopy to study the effects of diet and lipid-lowering therapy on plaque development in apolipoprotein (APO) E*3-Leiden transgenic mice...