2-Nitroimidazole is radiosensitizer and serves as imaging contrast agent by 19Fand 31P MR methods. Despite the success of mesonidazole and SR-4554 compounds, very little is known of its hepato-cytotoxicity if it can be potential hypoxia imaging marker and non-toxic drug. Authors established the low oxygen, low energy metabolic ratio and gluconeogenesis in nitroimidazole induced hepatocytes and ...

Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using (18)F-FDG, (64)Cu-ATSM, and (18)F-FLT before,...

in the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. among the ligands tested, diacetyl-bis(n4-methylthiosemicarbazones) (atsm) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde bis(n4-methyl)thiosemicarbazone (ptsm) was shown to possess low toxicity (7% let...

ATSM in a rabbit model Xingyu Nie1, 2, Richard Laforest1, Andrew Elvington3, Gwendalyn J. Randolph3, Jie Zheng1, Tom Voller1, Dana R. Abendschein3,4, Suzanne E. Lapi1, 2, 3, Pamela K. Woodard1, 2, 5 Affiliations 1. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA 2. Department of Biomedical Engineering, Washington University in St. Louis, MO, USA...

Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour regression. Tumour hypoxia can be detected by non-invasive techniques but the interrelationship between these techniques needs to be better defined. [18F]Fluoromisonidazole (18F-MISO) and Cu-labelled diacetyl-bis(N(4)-methylthiosemicarbazone (Cu-ATSM) PET, and...

This article first of all presents an innovative application of Real-Time Simulation Monitoring (RTSM), defined hereafter as “hydro-cloning”, developed by Power Vision Engineering. Second, a successful implementation of hydro-cloning is presented for the 170 MW La Bâtiaz hydroelectric power plant, HPP, owned and operated by Electricité d’Emosson SA, in the Canton of Wallis, Switzerland. The “Hy...

OBJECTIVE Application of distinct positron emission tomography (PET) scan reconstruction algorithms can lead to statistically significant differences in measuring lesion functional properties. We looked at the influence of two-dimensional filtered back projection (2D FBP), two-dimensional ordered subset expectation maximization (2D OSEM), three-dimensional ordered subset expectation maximizatio...