herein, we described the first case of self-inoculation in a veterinarian with bovine johne’s disease(bjd) attenuated vaccine in iran that required medical attention. a needle-stick injury to the right thumb of ayoung veterinarian during vaccination of cattle with bjd vaccine resulted in an inflammation that not onlyfailed to resolve but also progressed to a lesion 2.5 cm in diameter. the usual...

While recombinant Listeria monocytogenes strains can be explored as vaccine candidates, it is important to develop attenuated but highly immunogenic L. monocytogenes vaccine vectors. Here, prfA* mutations selected on the basis of upregulated expression of L. monocytogenes PrfA-dependent genes and proteins were assessed to determine their abilities to augment expression of foreign immunogens in ...

We showed previously that a single intranasal vaccination of mice with a recombinant vesicular stomatitis virus (VSV) expressing an influenza virus hemagglutinin (HA) protein provided complete protection from lethal challenge with influenza virus (A. Roberts, E. Kretzschmar, A. S. Perkins, J. Forman, R. Price, L. Buonocore, Y. Kawaoka, and J. K. Rose, J. Virol. 72:4704-4711, 1998). Because some...

FORMAL, SAMUEL B. (Walter Reed Army Institute of Research, Washington, D.C.), T. H. KENT, H. C. MAY, A. PALMER, AND E. H. LABREC. Protection of monkeys against experimental challenge with a living attenuated oral polyvalent dysentery vaccine. J. Bacteriol. 91:17-22. 1966.-Virulent strains of Shigella flexneri lb, S. flexneri 3, and S. sonnei I were mated with an Hfr strain of Escherichia coli K...

conditions is not new; history tells us of the many benefits of microbes to man. Their potential in the prevention and treatment of a wide range of disease conditions has been recognised since the days of Jenner, who in 1796 inoculated a young boy with cowpox and later with smallpox. The use of modified non-virulent species, attenuated bacteria/viruses and purified parts of micro-organisms has ...