Lifelong antibody responses to vaccination require reorganization of lymphoid tissue and dynamic intercellular communication called the germinal center reaction. B lymphocytes undergo cellular polarization during antigen stimulation, acquisition, and presentation, which are critical steps for initiating humoral immunity. Here, we show that germinal center B lymphocytes asymmetrically segregate ...

This chapter details a case study of 44-year-old Caucasian woman who was presented with 10-day history dry cough, exertional dyspnea, myalgia and fever. Symptoms persisted despite having completed course amoxicillin erythromycin. She an ex-smoker 15 pack years living in rented accommodation mold bird exposure, canary as pet. On the basis clinical hematological findings, cold antibody-induced he...

Conducting routine allergy tests of cattle with a simultaneous sample in TB-prone farms is necessary to confirm the stage epizootic process. The purpose research – explore pathomorphological changes cows upon detection para allergic reactions during diagnostic testing for tuberculosis. diagnosis tuberculosis animals was performed comprehensively using all methods control provided guidelines epi...

The characteristics of antibody-forming cell (AFC) progenitors lacking previous contact with specific antigen (virgin AFC progenitors) has been studied using sedimentation velocity and buoyant density separation for the investigation of physically distinct B-cell subpopulations. Functional characterization of isolated subsets was made using a quantitative adoptive immune assay for the IgM AFC p...

The web of causation is closing in on EB virus in its relation to certain conditions. In heterophile positive infectious mononucleosis the web of causation seems established beyond any reasonable doubt (1-3). The evidence derived from prospective serological studies that EBV antibody is regularly absent prior to infectious mononucleosis and regularly appears during illness (4-7) is supported by...

The aim was to evaluate the cellular immune response in atypical tuberculosis and granulomatous inflammation consistent with tuberculosis (TBC), negative histochemically for acid-fast bacilli and analysed by PCR for Mycobacterium tuberculosis (MT) detection in paraffin-embedded tissue. Thirty six samples of differently localized atypical tuberculous lesions and granulomatous tuberculoid lesions...

BACKGROUND Epstein Barr virus (EBV) plays a causal role in some diseases, including infectious mononucleosis, lymphoproliferative diseases and nasopharyngeal carcinoma. Detection of EBV infection has been shown to be a useful tool for diagnosing EBV-related diseases. In the present study, we compared the performance of molecular tests, including fluorescence in situ hybridization (FISH) and EBV...

CONTACT WITH CORAL MAY CAUSE A RARE TYPE OF CONTACT DERMATITIS, AND THE RESULTING SKIN REACTION CAN BE DIVIDED INTO DIFFERENT REACTIONS: the acute, delayed and chronic types of coelenterate dermatitis. Granulomas of delayed skin reactions have rarely been reported. Herein, we report on a rare case of a delayed reaction of the skin to coral injury, and the patient displayed superficial granuloma...

Epsten-Barr virus oropharyngeal shedding has been demonstrated in infectious mononucleosis patients many months after acute illness and long after the disease hallmarks, atypical lymphocytes and heterophile antibody, have disappeared. Extracellular virus is present more frequently in saliva than in other oropharyngeal samples. Prolonged excretion of EBV in asymptomatic carriers explains the dif...

N ULTRASTRUCTURAL COMPARISON of the cells which develop in cultures of mixtures of lymphocytes from allogenic donors and those which result from stimulation by phytohemagglutinin ( PHA ) has demonstrated morphologic differences. One of the most striking of these is the frequent presence of bundles of fibrils in transformed lymphocytes of tile mixed lymphocyte cultures. There have been scattered...