Two variants of the IL-4R alpha-chain (IL-4Ralpha) gene have been recently identified in association with different atopic disorders. To clarify the etiological relationship between the two variants, we analyzed responsiveness to IL-4 of transfectants with four kinds of IL-4Ralpha carrying either Val or Ile at 50 and either Gln or Arg at 551. The substitution of Ile for Val augmented STAT6 acti...

Consider a constraint on a sequence of variables functionally determining a result variable that is unchanged under reversal of the sequence. Most such constraints have a compact encoding via an automaton augmented with accumulators, but it is unknown how to maintain domain consistency efficiently for most of them. Using such an automaton for such a constraint, we derive an implied constraint b...

This paper deals with systems of fuzzy inequalities. It shows that a system of fuzzy inequalities with piecewise linear membership functions can be converted to a one-constraint nonlinear programming problem by employing the concepts of constraint surrogation and maximum entropy. An augmented Lagrangean algorithm is then applied to solve the resulting problem. Some computational results are inc...

Power flow (PF) analysis of microgrids (MGs) has been gaining a lot attention due to the evolution islanded MGs. To calculate MGs’ PF solution, globally convergent technique is proposed using Differential Evolution (DE)- popular optimization algorithm for global non-convex optimization. This paper formulates problem as constrained (COP) considering all operating conditions Droop Controlled Isla...

We propose to compute a sparse approximate inverse Cholesky factor $L$ of dense covariance matrix $\Theta$ by minimizing the Kullback--Leibler divergence between Gaussian distributions $\mathcal{N}(0, \Theta)$ and L^{-\top} L^{-1})$, subject sparsity constraint. Surprisingly, this problem has closed-form solution that can be computed efficiently, recovering popular Vecchia approximation in spat...

The Etherington reciprocity theorem, or distance duality relation (DDR), relates the mutual scaling of cosmic distances in any metric theory gravity where photons are massless and propagate on null geodesics. In this paper, we make use DDR to build a consistency check based its degeneracy with Hubble constant, $H_0$. We parameterise using form $\eta(z) = 1+ \epsilon z$, thus only allowing small...

Shape-constrained convex regression problem deals with fitting a function to the observed data, where additional constraints are imposed, such as component-wise monotonicity and uniform Lipschitz continuity. This paper provides unified framework for computing least squares estimator of multivariate shape-constrained in $${\mathbb {R}}^d$$ . We prove that is computable via solving an essentially...

There are many important practical optimization problems whose feasible regions not known to be nonempty or not, and optimizers of the objective function with least constraint violation prefer found. A natural way for dealing these is extend nonlinear problem as one optimizing over set points violation. This leads study shifted problem. paper focuses on constrained convex The sufficient conditi...

Abstract According to the increasing carbon dioxide released through vehicles and shortage of water resources, decision-makers decided combine environmental economic effects in Agri-Food Supply Chain Network (AFSCN) developing countries. This paper focuses on citrus fruit supply chain network. The novelty this study is proposal a mathematical model for three-echelon AFSCN considering simultaneo...