The cellular mechanism(s) underlying autism spectrum disorders (ASDs) are not fully understood although it has been shown that various genetic and environmental factors contribute to their etiology. As increasing evidence indicates that astrocytes and microglial cells play a major role in synapse maturation and function, and there is evidence of deficits in glial cell functions in ASDs, one cur...

how to cite this article: babaknejad n, sayehmiri f, sayehmiri k, mohamadkhani a, bahrami s. the relationship between zinc levels and autism: systematic review and meta-analysis. iran j child neurol. autumn 2016; 10(4):1-9.   abstract objective autism is a complex behaviorally defined disorder. there is a relationship between zinc (zn) levels in autistic patients and development of pathogenesis...

objectives: autism spectrum disorder (asd) is a group of neurodevelopment syndromes with impairments in social communications and restrictive or repetitive behaviors. neurofeedback is a new method that may regulate neuro and metabolic function in brain. this study is semi-experimental, with pre and post test.  methods: in 26 children with asd, 40 sessions of neurofeedback were done. brain waves...

OBJECTIVE Evidence from prospective studies of high-risk infants suggests that early symptoms of autism usually emerge late in the first or early in the second year of life after a period of relatively typical development. The authors prospectively examined white matter fiber tract organization from 6 to 24 months in high-risk infants who developed autism spectrum disorders (ASDs) by 24 months....

Intellectual and developmental disabilities (IDDs) such as autistic spectrum disorders (ASDs) and epilepsies are heterogeneous disorders that have diverse etiologies and pathophysiologies. The high rate of co-occurrence of these disorders, however, suggests potentially shared underlying mechanisms. A number of well-known genetic disorders share epilepsy, intellectual disability, and autism as p...

Mutations in the PTEN gene are associated with a broad spectrum of disorders, including Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome, Proteus syndrome, and Lhermitte-Duclos disease. In addition, PTEN mutations have been described in a few patients with autism spectrum disorders (ASDs) and macrocephaly. In this study, we screened the PTEN gene for mutations and deletions in 88 patient...

We examined the impact of simultaneous bottom-up visual influences and meaningful social stimuli on attention orienting in young children with autism spectrum disorders (ASDs). Relative to typically-developing age and sex matched participants, children with ASDs were more influenced by bottom-up visual scene information regardless of whether social stimuli and bottom-up scene properties were co...

Autism spectrum disorders (ASDs) and related neurological disorders are associated with mutations in many genes affecting the ratio between neuronal excitation and inhibition. However, understanding the impact of these mutations on network activity is complicated by the plasticity of these networks, making it difficult in many cases to separate initial deficits from homeostatic compensation. He...

Autism spectrum disorders (ASDs) are lifelong developmental disabilities. This group of disorders includes autistic disorder, Asperger syndrome, and pervasive developmental delay not otherwise specified. These disorders are presented from birth or very early during development and affect essential human behaviors such as social interaction, the ability to communicate ideas and feelings, imagina...

The present study evaluated the hypothesis that autism spectrum disorders (ASDs) are best represented as a discrete category distinct from typical behavior within autism-affected families. The latent structure, categorical versus dimensional, of ASDs informs future diagnostic revisions, clinical assessment, and the design of future research. Data were obtained from Interactive Autism Network, a...