Using a recently described technique for direct expansion of human T-lymphocytes isolated from small intestine biopsies, we have investigated the local cellular immune response in six patients with B-cell lymphomas of various subtypes. T-cell lines (TCL) were established by seeding tumor-infiltrating T-lymphocytes (T1TL) at limiting dilution in the presence of irradiated feeder cells in culture...

Postinfarct cardiac hypertrophy is an independent risk factor for heart failure and sudden death. Regression of cardiac hypertrophy has emerged as a promising strategy in the treatment of myocardial infarction (MI). Here we hypothesized that frizzled1 (FZD1), a receptor of the canonical Wnt signaling pathway, is a novel mediator of ischemia-associated cardiac hypertrophy. MI was induced in mice...

Clemens von Pirquet, his Life and Work, by RICHARD WAGNER, London, Oxford University Press, 1968, pp. xx, 214, illus., 66s. 6d. This fascinating biography should be read by every medical practitioner and many scientists. Its appearance is timely, for von Pirquet's pioneer work on allergy (the term he originated) has a bearing on the 'new immunology', including reactions (autoimmunization) invol...

BACKGROUND Transfusions are the primary therapy for thalassemia but have significant cumulative risks. In 2004, the Centers for Disease Control and Prevention (CDC) established a national blood safety monitoring program for thalassemia. This report summarizes the population and their previous nonimmune and immune transfusion complications. STUDY DESIGN AND METHODS The CDC Thalassemia Blood Sa...

Identification of the immunogens responsible for the production of pathogenic autoantibodies is a major problem in the field of autoimmunity. In the principal diseases that are thought to involve autoimmunization, rheumatoid arthritis, type I diabetes, and multiple sclerosis are examples, the instigating stimulus is unknown. Another example of the gap in our knowledge of disease-causing immunog...

All the major diseases of the gastrointestinal tract occurring in a temperate country like Great Britain are of unknown aetiology. Efficient public health measures and the development of sulphonamides, antibiotics, and vermifuges have sharply reduced the amount and severity of disease directly caused by the infections and infestations. Side by side with this improvement, chronic duodenal ulcer,...

The progress of medicine leads to the creation of new medical specialties. Such is the case of internal medicine, from which, among others, rheumatology, geriatrics, cardiology and pulmonology developed. Dynamic progress of oncology and of its main specialties – oncological surgery, radiotherapy and clinical oncology (oncological chemotherapy) – led, on one hand to the emergence of the new spec...

Recent years, more and more cities have planned to build “digital city”. In which the city information and its services is the core of urban plan, construction and management. of all the city informations, the spatial information plays an important role, compared with the other informations,there are some specialities in the urban spatial information, such as large scale, high resolving power,b...