The systemic administration of interleukin-2 (IL-2) can lead to significant antitumor responses in some patients with metastatic cancer in whom standard therapy has failed. A limitation of this immunotherapy is the toxicity associated with IL-2 infusion. To assess toxicity, we determined aspartate aminotransferase (AST; EC 2.6.1.1), alanine aminotransferase (ALT; EC 2.6.1.2), gamma-glutamyltran...

Serum biochemical traits constitute important panels in the clinical diagnosis, prognosis and treatment of livestock diseases via the investigations of myriads of parameters influencing these biochemical references. Sixty clinically healthy animals of three extant breeds of Nigerian native sheep (20 Balami: 20 Yankassa and 20 Uda) were sampled to examine the roles of breed, age and sexual dimor...

Granulocyte function in burn injury has been evaluated with an in vitro animal assay. Bactericidal activity, using this technique, was markedly depressed only when granulocytes from scald burned rats were challenged with each of three strains of Pseudomonas aeruginosa in the presence of autologous postburn serum or heat-inactivated serum. Preincubation of postburn and normal serum at 37 degrees...

This study aims to synthesize Platinum nanoparticles (Pt NPs) using Olive leaves extract's environmentally friendly approach. UV-Visible spectroscopy has been used follow the turning of Pt +4 ions Pt0 NPs. X-ray diffraction (XRD) investigate as-synthesized NPs and its cubic face-centered structure crystallinity. The average size was 9.2 nm, calculated by transmission electron microscopy (TEM). ...

Cellular replacement therapy for diabetes mellitus (DM) has received much attention. In this study, we investigated the effect of transplantation of autologous bone marrow‑derived mesenchymal stem cells (ABMSCs) in streptozotocin (STZ)‑induced diabetic miniature pigs. Miniature pig BMSCs were cultured, labeled with superparamagnetic iron oxide (SPIO) and transplanted into the pancreas of diabet...

Rapid diagnostic testing with matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) decreases the time to organism identification by 24 to 36 h compared to the amount of time required by conventional methods. However, there are limited data evaluating the impact of MALDI-TOF with real-time antimicrobial stewardship team (AST) review and intervention on antimicrobial prescribing...

INTRODUCTION The management of Mooren's ulcer can be a challenge for clinicians. OBJECTIVE To report a case of Mooren's ulcer treated with amniotic membrane transplantation supplemented with autologous serum eye drops. CASE REPORT A 22-year-old male presented with history of pain, redness, watering and diminution of vision of the right eye for one year. Examination of his eyes revealed the ...

BACKGROUND/AIM Intima media thickness (IMT) and stiffness of the carotid arteries is related to coronary artery disease, and chronic renal failure patients are at high risk for such diseases. An oral adsorbent, AST-120 (Kremezin; Kureha Chemical Industry, Tokyo, Japan), can delay the progression of chronic renal failure in undialyzed uremic patients. The aim of the present study was to determin...

INTRODUCTION In spite of tremendous progress in the medical and surgical treatment of children with congenital heart disease and dilated cardiomyopathy achieved during the past few decades, for some children a heart transplant remains the only option. Clinically relevant benefits of intracoronary injection of autologous stem cells on cardiac function and remodelling have been demonstrated in ad...

BACKGROUND Stearic acid is known as a potent anti-inflammatory lipid. This fatty acid has profound and diverse effects on liver metabolism. The aim of this study was to investigate the effect of stearic acid on markers of hepatocyte transplantation in rats with acetaminophen (APAP)-induced liver damage. METHODS Wistar rats were randomly assigned to 10-day treatment. Stearic acid was administe...