Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin--originating solely from a single microorganism isolated at the Kitasato Institute, Tokyo, Japan from Japanese soil--has had an immeasurably beneficial impact in improving the lives and welfare of billions of people throughout the world. Originally introduced as a veterinary drug, it kills a wide ra...

Invasive diseases of horses are an urgent problem in the horse breeding industry Republic Belarus, as well near and far abroad countries. The main role among parasitic pathology is occupied by helminths small large intestine, larvae gasterophilus. In associative course, they cause significant economic losses associated with growth development sick young animals, reduced performance, endurance i...

Second-stage juveniles (I2) of Meloidogyne arenaria consumed more oxygen (P </= 0.05) than M. incognita J2, which in turn consumed more than M. javanica J2 (4,820, 4,530, and 3,970 mul per hour per g nematode dryweight, respectively). Decrease in oxygen consumption depended on the nematicide used. Except for aldicarb, there was no differential sensitivity among the three nematode species. Meloi...

Our laboratory is investigating ivermectin (IVM) and other members of the avermectin family as new pharmaco-therapeutics to prevent and/or treat alcohol use disorders (AUDs). Earlier work found that IVM significantly reduced ethanol intake in mice and that this effect likely reflects IVM's ability to modulate ligand-gated ion channels. We hypothesized that structural modifications that enhance ...

Heavy-ion irradiation technology has advantages over traditional methods of mutagenesis. Heavy-ion irradiation improves the mutation rate, broadens the mutation spectrum, and shortens the breeding cycle. However, few data are currently available regarding its effect on Streptomyces avermitilis morphology and productivity. In this study, the influence of heavy-ion irradiation on S. avermitilis w...

The effects of insecticides on arrhenotokous and thelytokous types in adult females onion thrips, Thrips tabaci Lindeman, collected from a total 13 sites Welsh onions, cabbages, onions Kyoto Prefecture, Japan, 2016 2017 were evaluated. Susceptibility to the tested varied among reproductive types, populations, years. Among 14 female adults type using kidney bean leaf dipping method, spinetoram, ...