Immune checkpoint blockade therapy by targeting the programmed death protein 1/programmed death ligand 1 (PD-L1) axis using antibodies has yielded promising clinical responses in patients with non-small cell lung cancer (NSCLC). However, owing to the dynamic expression of PD-L1, degree of mutational/neoantigen load, intratumoral heterogeneity, infiltrated immune cells of tumor microenvironment ...

introduction: mechanical stimulation of human mesenchymal stem cells has demonstrated changes in many cell behaviours such as adhesion, migration, growth and differentiation through mechanotransductive pathways. these include experiments on effect of nanotopography 1, shear stress, stiffness of extracellular matrix 2, strain, stress and acoustic wave energy 3 on cells. in this research we were ...

in the near future the use of distributed generation systems will play a big role in the production ofelectrical energy. one of the most common types of dg technologies , fuel cells , which can be connectedto the national grid by power electronic converters or work alone studies the dynamic behavior andstability of the power grid is of crucial importance. these studies need to know the exact mo...

original article background and objectives: one type of electromagnetic fields, based on frequency range, is extremely low frequency (elf) fields. there are lots of reports about measuring elf- magnetic field (mf) in substations, power plants, cities, near high voltage power lines and etc. this study aimed to compare the difference between measurement of three-axis and single-axis probe mf mete...

introduction: many studies have been performed to evaluate the stress distribution around endodontic posts; those which compared posts composed of different materials are rare. the aim of this study was to compare stresses induced in dentin by three structurally different posts using photoelasticity method. materials and methods: nine blocks of psm-5 photoelastic material with 45×45×10 mm dimen...

In this paper, the design and implementation of adaptive speed controller for a sensorless synchronous reluctance motor (SynRM) drive system is proposed. A combination of well-known adaptive input-output feedback linearization (AIOFL) and adaptive backstepping (ABS) techniques are used for speed tracking control of SynRM. The AIOFL controller is capable of estimating motor two-axis inductances ...

background previous studies using cell culture systems for the replication of hepatitis c virus have opened new research dimensions, and paved the ways for further and detailed studies of the virus in vitro. objectives the purpose of the present study was to cultivate hepatitis c virus in a cell culture system and evaluate viral amplification. materials and methods in order to propagate hepatit...

BACKGROUND Recent studies have shown that the inflammatory process, including the biomarker production, and the intense activation of innate immune responses are greater in the malaria caused by Plasmodium vivax than other species. Here, we examined the levels of serum biomarkers and their interaction during acute malaria. MATERIAL AND METHODS Blood samples were collected from P. vivax-infect...

Abstract Normal walking is the most action impose on the skeleton structure. The microarchitecture of trabecular bone plays an important role respect to mechanical properties. Analyse the fatigue behaviour of the trabecular bone respect to physiological activity (Normal Walking), subjected to combination of axial compression and torsional (multi-axial) load counted as the main aim of this study...