Tumor Reduction In article 2202932 by María Sancho-Albero, Luisa De Cola, and co-workers, a prodrug, based on Pt(IV) complex, encapsulated in nanocage, is activated upon the destruction of carrier exerts antitumoral activity hard-to-treat mesothelioma cancer.

Plasmodiophora brassicae, the causal agent of clubroot disease of the Brassica crops, is widespread in the world. Quantitative trait loci (QTLs) for partial resistance to 4 different isolates of P. brassicae (Pb2, Pb4, Pb7, and Pb10) were investigated using a BC1F1 population from a cross between two subspecies of Brassica rapa, i.e. Chinese cabbage inbred line C59-1 as a susceptible recurrent ...

Protein nanocages play crucial roles in sub-cellular compartmentalization and spatial control all domains of life have been used as biomolecular tools for applications biocatalysis, drug delivery, bionanotechnology. The ability to their assembly state under physiological conditions would further expand practical utility. To gain such control, we introduced a peptide capable triggering conformat...

For two important metal oxides (MO, M=Mg, Zn) we predict, via accurate electronic structure calculations, that new low-density nanoporous crystalline phases may be accessible via the coalescence of nanocluster building blocks. Specifically, we consider the assembly of cagelike (MO)_{12} clusters exhibiting particularly high gas phase stability, leading to new polymorphs with energetic stabiliti...

Nonlinear optical materials have gained immense scientific interest in the recent times owing to their vast applications various fields. Continuous strides are made design and synthesize with large nonlinear response high thermodynamic stability. In this regard, we present here bi-alkali metal doping on boron phosphide nanocage as a new strategy thermodynamically stable response. The geometric,...

OBJECTIVE To study clinical, morphological and molecular characteristics in a Swiss family with autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI). PARTICIPANTS AND METHODS A 15-month-old girl presenting with symptoms of polydipsia and polyuria was investigated by water deprivation test. Evaluation of the family revealed three further family members with symptomatic vaso...

Protein assemblies with cage-like structures are found widely in Nature a large diversity of structural properties and functionalities. These architectures provide both inspiration for biomimetic design templates bioengineering. Inspired by the native utility protein nanocage (PNC) cargo loading, transport, protection, significant effort has been put into development PNC-based biomedical applic...