The role of hCG as a stimulator of the human thyroid has been a subject of controversy, because discrepant results have been obtained in different in vitro assays. In an attempt to explain the variation observed in the thyroid response to hCG, we investigated the ability of hCG and that of its isoforms and glycosylation variants to inhibit [125I]bovine (b) TSH binding and stimulate adenylate cy...

Purpose To compare the efficacy of two regimens of low dose human chorionic gonadotropin (hCG) on follicular response and oocyte maturation in women with polycystic ovarian syndrome (PCOS). Methods Ninety women with PCOS who underwent assisted reproduction were eligible for this controlled, prospective, randomized study. Our trial was performed at Royan Institute Reproductive Research Center ov...

Background & Objective: The objective of this study was to determine the association between maternal serum concentration PAPP-A and free B-HCG at 11-13(+6) weeks uterine artery pulsatility index (PI) 30-34 with prediction preeclampsia.Materials Methods: This cohort performed on 882 women singleton pregnancies from March 2018 November 2020 university hospital (referred center) in Ahvaz/Khuzesta...

BACKGROUND The evaluation of prepubertal gonadal Leydig cells secretion requires gonadotropin stimulation. Urinary hCG (human chorionic gonadotropin) is currently unavailable in many countries, however, recombinant hCG (rhCG) can be used. Our aim was to evaluate rhCG-stimulated testicular hormones in a group of patients with cryptorchidism. METHODS We evaluated 31 prepubertal boys (age range,...

A 27-year-old second gravid was admitted with history of amenorrhea of 8 weeks’ duration with lower abdominal pain and spotting per-vaginum of 2 days’ duration. Her vitals were stable, and abdominal examination revealed a soft bulky 6 weeks’ size uterus. Cervical motion tenderness was absent. In view of a positive urine pregnancy test, an urgent transvaginal ultrasound was performed, which reve...

hCG exists in two analogous structures, as typified by the hormone hCG which binds an LH/hCG hormone receptor and the TGFß receptor binding autocrine hyperglycosylated hCG. Both share a common α-subunit and ß-subunit amino acid sequence. From the common hormone hCG and autocrine hyperglycosylated hCG structures there are seven common hCG variants with wildly varying hormone hCG or autocrine hyp...

Progestin-primed ovarian stimulation (PPOS) protocol has recently been demonstrated to be an novel regimen for preventing premature LH surges during controlled ovarian hyperstimulation (COH) in combination with frozen-thawed embryo transfer (FET). Our prospective controlled study was to explore the effect of human chorionic gonadotropin (hCG) contained in human menopausal gonadotropin (hMG) on ...

Aim: This study was conducted to investigate placenta-associated plasma protein (PAPP-A) and free human chorionic gonadotropin (B-hCG) levels after blastocyst transfer versus cleavage-stage embryo transfer. 
 Materials method: A total of 449 women were included in this rerospective sudy. The consisted two groups: Group 1: pregnant conceived by intracytoplasmic sperm injection (ICSI) proced...

The progress and current status of vaccines which induce antibodies against human chorionic gonadotrophin (HCG) and luteinizing hormone-releasing hormone (LHRH) are reviewed. Three vaccines devised against HCG have undergone phase I clinical trials documenting their safety, and reversibility. One of these, the heterospecies dimer (HSD)-HCG vaccine has also completed phase II efficacy trials in ...