Bacopa monniera is locally referred as Brahmi Shak, has been reputed to use in the Ayurvedic system of medicine for centuries. In our ongoing study to identify the scavenger of ONOO from natural sources, the aerial parts of Bacopa monniera Linn. was evaluated to scavenge authentic peroxynitrites (ONOO) and to inhibit total reactive oxygen species (ROS) generation, in kidney homogenates using 2'...

Mutations were induced in tissue cultured raised Bacopa monnieri (L.) plantlets by treating in vitro derived leaves with gamma rays at (γ – rays) dose rate of 0, 10, 20, 40 and 80 gray (Gy) and 0.5% of ethyl methanesulphonate (EMS) at 0, 0.5, 1.0, 1.5, 2.0 and 2.5 hours (h). Xantha mutants were observed with γ rays at 10, 20 and 40 Gy. All the leaf explants treated with 80 Gy were either necrot...

BACKGROUND Bacopa monnieri is a medicinal plant which has long been used in Ayurvedic medicines to augment brain function and to improve memory. The purpose of our study was to identify and evaluate possible toxic effects of B. monnieri extract in rats by assessing hematological, biochemical, and histopathological parameters. METHODS Acute oral toxicity of Bacopa monnieri extract was studied ...

Bacopa monniera (Bm), commonly known as brahmi, is widely used in the Indian System of Medicine as a notropic agent. The present study was designed to investigate the effects of oral administration of Bm (25, 75 and 150 mg/kg) for 21 days on: (i) myocardial antioxidant system and (ii) oxidative stress induced by isoproterenol (ISP) in the rat heart. Oral administration of Bm (75 and 150 mg/kg) ...

Current discovery demonstrates the rapid formation of platinum nanoparticles using leaf extract of a neurobeneficial plant, Bacopa monnieri (BmE). The nanoparticles (BmE-PtNPs) were stabilized and then coated with varied phytochemicals present within the leaf extract. These nanoparticles demonstrated the same activity of Complex I, as that of oxidizing NADH to NAD(+) using a spectrophotometric ...

A prospective cohort, noncomparative, multicenter trial was conducted to explore the potential of a phytotherapeutic compound, available as a dietary supplement and containing extracts of Bacopa monnieri and Haematococcus pluvialis (astaxanthin) plus phosphatidylserine and vitamin E, in improving cognition in subjects diagnosed with mild cognitive impairment. Enrolled subjects (n=104) were aged...

Bacopa monnieri and the constituents of this plant, especially bacosides, possess various neuropharmacological properties. Like drugs, some herbal extracts and the constituents of their extracts alter cytochrome P450 (CYP) enzymes, causing potential herb-drug interactions. The effects of Bacopa monnieri standardized extract and the bacosides from the extract on five major CYP isoforms in vitro ...