elevated amounts of free radicals due to ionizing radiation have damaging effects on the body. h2-receptor antagonists have potential oxygen radical scavenging properties. we tried to determine the effects of two h2-receptor antagonists (cimetidine and ranitidine) on lipid peroxidation (lpo) and lipid profile (lp) in plasma and liver of γ-irradiated (1gy/day for 3 days) balb/c mice. the control...

conclusions this case showed the effect of additional anakinra on children with fmf who were colchicine resistant. case presentation herein was reported a colchicine non-responsive patient with accurate diagnosis and early treatment of fmf. she had presented with recurrent and persistent acute abdominal pain attacks and several abdominal surgeries. addition of recombinant interleukin-1 receptor...

background: polycystic ovarian syndrome (pcos) patients are prone to premature lh surge and ovarian hyperstimulation syndrome (ohss). long gnrh analogue protocol and gnrh antagonist protocol are two methods utilized for induction ovulation in patients undergoing ivf/icsi. objective: the aim of this study was to compare the effects of gnrh agonists and antagonists in pcos patients. materials and...

background : an accurate and prompt diagnosis of bacterial arthritis is essential for earlier treatment and a good outcome. superantigens produced by staph. aureus are among the most lethal toxins. the paper objective was identification of common bacterial antigens and s.aureus superantigens in synovial fluid (sf) of children with negative culture and direct smear for other bacteria except for ...

Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [112]) are activated endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for antagonist-bound [155, 316, 224, 62], agonist-bound [379, 205, 206] and G protein-bound A2A [49] have been described. The of an A1 receptor [130] adenosine-bound receptor-Gi complex [87] resolve...

The trafficking of monocytes across the endothelial lining of the blood vessel increases in response to bacterial infection at sites of inflammation. However, the molecular events involved in the diapedesis of monocytes in response to endotoxin are not completely understood. Our studies revealed that signaling by lipopolysaccharide (LPS) in human umbilical vein endothelial cells (HUVEC) resulte...

ABSTRACT Fire blight of apple and pear is initiated by epiphytic populations of Erwinia amylovora on flower stigmas. Predicting this disease and managing it with microbial antagonists depends on an understanding of bacterial colonization on stigmas. Detached 'Manchurian' crab apple flowers were inoculated with E. amylovora and subjected to a range of constant temperatures or various fluctuating...

Arginine-phenylalanine-amide (RFamide)-related peptides known as neuropeptide VF (NPVF) have a crucial role in feeding regulation. The present study purposed to determine the effect of intracerebroventricular (ICV) injection NPVF on dietary intake and possible interactions with glutamate opioid systems broiler chicken. In experiment 1, chickens received ICV administration control solution, (16 ...

Hypoxia-inducible factor (HIF)-1α, is a transcription factor that controls energy metabolism and angiogenesis under hypoxic conditions, and a potent regulator of innate immunity. The studies described herein examined the role of HIF-1α in disease resolution in BALB/c (resistant, cornea heals) mice after ocular infection with Pseudomonas (P.) aeruginosa. Furthermore, the current studies focused ...