Myeloproliferative neoplasms (MPNs) frequently have an activating mutation in the gene encoding Janus kinase 2 (JAK2). Thus, targeting the pathway mediated by JAK and its downstream substrate, signal transducer and activator of transcription (STAT), may yield clinical benefit for patients with MPNs containing the JAK2(V617F) mutation. Although JAK inhibitor therapy reduces splenomegaly and impr...

This special issue of Computing and Visualization in Science contains selected papers from the 2014 European Multigrid conference (EMG 2014), which took place in Leuven, Belgium, from 9 to 12 September, 2014. European Multigrid (EMG) is a series of conferences on the theme of multigrid methods and related fields. EMG is one of the most important conference series on this topic worldwide. Previo...

The timing and the frequency of punishment are critical elements in law enforcement. Previous studies suggest the superiority of immediate punishment schemes over delayed punishment, as well as the importance of frequent punishment. Yet law enforcement schemes which utilize both frequent and immediate punishment may be cost prohibitive in real settings. In this work, we propose the “bad lottery...

background: the manner in which healthcare professionals deliver bad news affects the way it is received, interpreted, understood, and dealt with. despite the fact that clinicians are responsible for breaking bad news, it has been shown that they lack skills necessary to perform this task. objectives: the purpose of this study was to explore iranian mothers’ experiences to receive bad news abou...

Corynebacterium glutamicum is currently used for the industrial production of a variety of biological materials. Many available inducible expression systems in this species use lac-derived promoters from Escherichia coli that exhibit much lower levels of inducible expression and leaky basal expression. We developed an arabinose-inducible expression system that contains the L-arabinose regulator...

Purpose: To investigate the effect of Pinellia polysaccharide on airway remodeling in cough-variant asthmatic rats, and involvement PI3K/AKT signal route process.
 Methods: Seventy-five Sprague-Dawley (SD) rats were assigned to 5 groups: blank control, model, low-dose (100 mg/kg), medium-dose (200 mg/kg) high-dose (400 groups, each with 15 rats. Immunoblot assay was employed measure relati...

Introduction: Cardiomyocytes apoptosis contributes to the development of left ventricular hypertrophy. The Bcl-2 family members are important regulators of mitochondrial pathway of apoptosis. Monoterpenoid phenol –carvacrol– possesses strong antioxidant properties. The present study aimed to evaluate the effect of carvacrol on transcription level of pro-apoptotic (Bad and Bax) and...

Genomic aberrations and gene expression-defined subtypes in the large METABRIC patient cohort have been used to stratify and predict survival. The present study used normalized gene expression signatures of paclitaxel drug response to predict outcome for different survival times in METABRIC patients receiving hormone (HT) and, in some cases, chemotherapy (CT) agents. This machine learning metho...