Baicalein is a flavone compound isolated from Scutellaria baicalensis Georgi (Huang Qin) which exerts multiple biological effects including anti-inflammatory, anti-apoptotic and anti-tumor. However, there is little known about the effects of baicalein on cathepsins and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in osteoarthritis (OA). In the present study, we invest...

Osteoporosis is a systemic skeletal disease that is characterized by low bone density and microarchitectural deterioration of bone tissue. The increasing prevalence of osteoporosis has attracted much attention. In this study, MC3T3-E1 pre-osteoblasts were treated with the natural compound, baicalein (0.1 μmol/L, 1 μmol/L, 10 μmol/L), to stimulate differentiation over a 14-day period. In additio...

Baicalein, a flavonoid isolated from the roots of Scutellaria baicalensis, is known to modulate γ-aminobutyric acid (GABA) type A receptors. Given prior reports demonstrating benefits of GABAA modulation for Alzheimer's disease (AD) treatment, we wished to determine whether this agent might be beneficial for AD. CHO cells engineered to overexpress wild-type amyloid precursor protein (APP), prim...

Baicalein was investigated for tumor cell-specific cytotoxicity, apoptosis-inducing activity and signal pathway against the MDA-MB-231 human breast cancer cell line. After the MDA-MB-231 cells had been treated with baicalein, trypan blue exclusion, propidium iodide (PI) assay and 4',6-diamidino-2-phenylindole (DAPI) were used to stain the dead cells and detect apoptosis, respectively. The effec...

We conducted this study to investigate whether baicalin, baicalein or schizandrin significantly affect MUC5AC mucin production induced by epidermal growth factor (EGF) or phorbol ester (PMA) in human airway epithelial cells. Confluent NCI-H292 cells were pretreated with varying concentrations of baicalin, baicalein or schizandrin for 30 min and then stimulated with EGF or PMA for 24 h, respecti...

OBJECTIVE β-Cell dysfunction plays a central role in the pathogenesis of type 2 diabetes (T2D), and the identification of novel approaches to improve β-cell function is essential to treat this disease. Baicalein, a flavonoid originally isolated from the root of Scutellaria Baicalensis, has been shown to have beneficial effects on β-cell function. Here, the authors investigated the molecular mec...

Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant and lethal human cancers in world due to its high metastatic potential, patients with PDAC have a poor prognosis, yet quite little understood regarding underlying biological mechanisms capacity. Baicalein has dramatic anti-tumor function treatment different types cancer. However, therapeutic effects baicalein on action not bee...

Acute lymphoblastic leukemia (ALL) accounts for approximately 75% of childhood leukemia, and chemotherapy remains the mainstay therapy. Baicalein is an active flavonoid used in traditional Chinese medicine and has recently been found to have anticancer, anti-inflammatory, and antiallergic properties. This study aims to investigate the molecular apoptotic mechanisms of baicalein in CCRF-CEM leuk...

Baicalin and baicalein are flavonoid compounds derived from Scutellaria baicalensis Georgi. These compounds have been used in the treatment of numerous diseases, including fibrotic diseases. However, research regarding their antifibrotic effects and mechanism of action in renal fibrosis is limited. In the present study, normal rat kidney interstitial fibroblast (NRK-49F) cells were stimulated w...

Gastrodin (GAS) is one of the rare traditional Chinese medicinal materials in our country and it has been widely used in the treatment of cardiovascular and cerebrovascular diseases. Baicalein is a traditional Chinese herbal medicine, the active ingredient of Scutellaria baicalensis Georgi has a wide range of pharmacological effects. in recent years Fan Jinghui et al found that baicalein has a ...