Direct sequencing remains the most widely used method for the detection of epidermal growth factor receptor (EGFR) mutations in lung cancer; however, its relatively low sensitivity limits its clinical use. The objective of this study was to investigate the sensitivity of detecting an epidermal growth factor receptor (EGFR) mutation from peptide nucleic acid-locked nucleic acid polymerase chain ...

This paper describes a high-gain CMOS low-noise amplifier (LNA) for 2.4/5.2-GHz WLAN applications. The cascode LNA uses an inductor at the common-gate transistor to increase its transconductance equivalently, and therefore it enhances the gain effectively with no additional power consumption. The LNA is matched concurrently at the two frequency bands, and the input/output matching networks are ...

A novel 2',4'-BNA/LNA analog bridged by guanidine, termed as guanidine bridged nucleic acid (GuNA), was synthesized and incorporated into oligonucleotides. Thermal stabilities and nuclease resistance of GuNA-modified oligonucleotides were investigated and compared with those of 2',4'-BNA/LNA and natural DNA oligonucleotides. GuNA exhibited interestingly high binding affinity towards complementa...

This paper presents a Low Noise Amplifier for UWB Radio Receiver at 8.72GHz using 0.18μm UMC Technology where 0.18μm technology is for lower power consumption. UWB Radio Receiver which made up in between the frequency range of 3.1GHz to 10.6GHz.The basic architecture of LNA comprises a RF amplifier in the middle of input matching network and the output matching network. We have designed a low n...

The Low Noise Amplifier (LNA) is very much important in achieving good reception sensitivity in the wideband transceiver of Ultra Wide Band (UWB) architecture. In this paper, the LNA is designed for Multi Band-Orthogonal Frequency Division Multiplexing (MB-OFDM) receiver, which is used to transmit the information on 14 different sub bands of UWB with minimum of 528 MHz frequency in each band. T...

Due to an increasing demand for simultaneous global roaming and all-in-one wireless phones, the interest in the development of the multi-standard transceivers has been increased. In the receiver front end, the performance of Low Noise Amplifier (LNA) decides overall receiver sensitivity and hence its design plays a crucial role. In this paper, an active inductor based tunable two-stage LNA empl...

Synthesis of chimeric 9-mer oligonucleotides containing methylphosphonate-linkages and locked nucleic acid (LNA) monomers, their binding affinity towards complementary DNA and RNA, and their 3'-exonucleolytic stability are described. The obtained methylphosphonate-DNA/LNA chimeric oligonucleotides display similarly high RNA affinity and RNA selectivity as a corresponding 9-mer DNA/LNA chimeric ...

Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excellent specificity toward complementary RNA and DNA oligonucleotides. The remarkable properties of LNA have led to applications within various gene silencing strategies both in vitro and in vivo. In the present review, we highlight the uses of LNA for regulation of gene expression with emphasis on RN...

We report the structure activity relationships of short 14-mer phosphorothioate gapmer antisense oligonucleotides (ASOs) modified with α-L-locked nucleic acid (LNA) and related modifications targeting phosphatase and tensin homologue (PTEN) messenger RNA in mice. α-L-LNA represents the α-anomer of enantio-LNA and modified oligonucleotides show LNA like binding affinity for complementary RNA. In...

This paper presents a 5.8 GHz low voltage and low power LNA design integrated in a TSMC 0.18 μm CMOS process, and its sensitivity analysis. This sensitivity analysis gives a measure of the sensitivity of the LNA performance to a change in the circuit element values, thereby assisting the designer choose the adequate circuit-element tolerances. Such sensitivity analysis of the LNA is very benefi...