OBJECTIVE To observe the effects of lead acetate and protective role of garlic extract on the histomorphology of the ovary in an animal model. METHODS The experimental trial was conducted at the Department of Anatomy, Army Medical College Rawalpindi, in association with the National Institute of Health (NIH), Islamabad, from April to June 2013. It comprised 30 adult non-pregnant female mice (...

Lofgren, Jennifer L. S., Melissa R. Mazan, Edward P. Ingenito, Kara Lascola, Molly Seavey, Ashley Walsh, and Andrew M. Hoffman. Restrained whole body plethysmography for measure of strain-specific and allergen-induced airway responsiveness in conscious mice. J Appl Physiol 101: 1495–1505, 2006. First published July 20, 2006; doi:10.1152/japplphysiol.00464.2006.—The mouse is the most extensively...

BACKGROUND Redox-active iron, a catalyst in the production of hydroxyl radicals via the Fenton reaction, is one of the key participants in ROS-induced tissue injury and general inflammation. According to our recent findings, an excess of tissue iron is involved in several airway-related pathologies such as nasal polyposis and asthma. OBJECTIVE To examine the anti-inflammatory properties of a ...

The aim of this study was to evaluate the capacity of BR55, an ultrasound contrast agent specifically targeting vascular endothelial growth factor receptor 2 (VEGFR2), to distinguish the specific anti-VEGFR2 therapy effect of sunitinib from other anti-angiogenic effects of a therapy (imatinib) that does not directly inhibit VEGFR2. Sunitinib, imatinib and placebo were administered daily for 11 ...

BACKGROUND Aflatoxin B1 (AFB1) is potent hepatotoxic and hepatocarcinogenic agent. In aflatoxicosis, oxidative stress is a common mechanism contributing to initiation and progression of hepatic damage. The aim of this work was to evaluate the hepatoprotective effect of cactus cladode extract (CCE) on aflatoxin B1-induced liver damage in mice by measuring malondialdehyde (MDA) level, the protein...

Biomaterial scaffolds are categorized into artificial or natural polymers, or combinations of the two. Artificial polymers often undergo serum protein adsorption, elicit foreign body and encapsulation immune responses post-implantation. Large pore bovine electrospun collagen I was therefore screened as a candidate for human keratinocyte and fibroblast cell scaffolds. Human HaCaT keratinocyte an...

In this study, it was aimed to investigate the effects of different diets on lipid peroxidation, antioxidants, proliferation and vasculogenesis in liver tissue. BALBC female rats (21) were divided as group fed with standard chow (SC), a ketogenic diet (KD) western (WD). The tap water rat specially prepared according determined for 4 weeks. Liver tissue oxidative damage, evaluated using spectrop...

Senyawa tanin yang terdapat di teh dapat membentuk kompleks mengakibatkan terjadinya obstruksi ureter, pembengkakan ginjal (Hidronefrosis). Prevelansi gagal Indonesia disebabkan hidronefrosis dari tahun ke terus meningkat pada 2011 jumlah penderita adalah 22.304 dan 2012 menjadi 28,782 kasus. Penelitian ini bertujuan untuk mengetahui prevalensi kejadian Musmuculus Bablc Albino diberikan ekstra ...