Immunohistochemistry is important for the accurate diagnosis of basal cells in atypical glandular proliferations of the prostate. p40, an isoform of p63, may be an adjunct to a marker panel in this setting. Biopsies of 68 patients were analyzed by immunohistochemistry using antibodies to 34betaE12 and p40. Basal cell staining was classified as negative, partial (<60%), or diffuse (≥60%); irregu...

objective: to determine the diagnostic value of blood cells surface markers in patients with acute appendicitis. methods: in this cross-sectional study, 71 patients who underwent appendectomy following a diagnosis of appendicitis were recruited during a one-year period. the patients were divided into two groups: patients with histopathologically confirmed acute appendicitis and subjects with no...

Ductal carcinoma in situ (DCIS) is a group of heterogeneous lesions genetically, morphologically, and biologically. Recently, breast epithelium in the terminal ductal lobular unit has been sub-classified based on the expression of several cytokeratin markers as stem cells (CK5/6 +), luminal cells (CK8, CK18 +), and basal cells (CK14, CK17 +). In this study we describe the relationship between D...

Inconsistent with the view that epidermal stem cells reside randomly spread along the basal layer of the epidermal rete ridges, we found that epidermal cells expressing stem cell markers in nonglabrous skin exist in direct connection with the distal end of the arrector pili muscle. The epidermal cells that express stem cell markers consist of a subpopulation of basal keratinocytes located in a ...

Ovarian fibromas are the most common benign solid ovarian tumors, which preoperative diagnosis often is difficult. Ovarian fibromas, especially in bilateral cases, may be representative of Gorlin syndrome.Gorlin syndrome (GS) is a rare autosomal dominant disorder with predisposition to basal cell carcinomas (BCCs) and other various benign and malignant tumors. To report a case of a young patien...

this case report describes a 59-year-old woman with a giant basal cell carcinoma on the face neglected for 11 years. surgical resection of the lesion resulted in a 13 × 11 cm defect. issues regarding the adequately safe surgical margins and the management of the resultant defect through modern wound dressing technologies are discussed. keywords : giant basal cell carcinoma, modern dressing, gel...

Tumor evolution and stable resistance state identification remains the main challenge for successful targeted tumor therapies. Previously our group has identified distinct cell trajectories in patient advanced basal carcinomas (BCCs) have molecular basis, surface markers for, reversibility of, transcription factor driver of to squamous carcinoma transition (BST). In addition differentiated stat...

Breast cancers with a basal-like gene signature are primarily triple-negative, frequently metastatic, and carry a poor prognosis. Basal-like breast cancers are enriched for markers of breast cancer stem cells as well as markers of epithelial-mesenchymal transition (EMT). While EMT is generally thought to be important in the process of metastasis, in vivo evidence of EMT in human disease remains...

Cutaneous carcinomas are malignant lesions, which most commonly occur on photo-aggressed site. The purpose of our study was to evaluate the immunohistochemical expression of three apoptotic markers (p53, Bax, and Bcl-2) in photoinduced basal and squamous cell carcinoma. The study was performed on 24 patients diagnosed with these forms of cutaneous carcinoma localized on photoexposed regions: 14...

Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...