Using molecular dynamics simulations, we study the effect of pressure on the binding propensity of small RNAs by calculating the free energy barrier corresponding to the looped out conformations of unmatched base, which presumably acts as the binding sites for ligands. We find that the free energy associated with base looping out increases monotonically as the pressure is increased. Furthermore...

The Henderson-Hasselbalch equation and the base excess have been used traditionally to describe the acid-base balance of the blood. In 1981, Stewart proposed a new model of acid-base balance based upon three variables, the "strong ion difference" (SID), the total weak acids (ATot), and the partial pressure of carbon dioxide (Pco2). Over 20 years later, Stewart's physiochemical model still remai...

A water jet machining is an industrial tool capable of cutting a wide variety of materials using a very high-pressure jet of water, or a mixture of water and an abrasive substance. This paper addresses the concept of the Intelligent knowledge base system (IKBS) for optimization of product design and manufacturing process for water jet machining in computer based concurrent engineering environme...