Pituitary tumor transforming gene (PTTG)-binding factor (PBF or PTTG1IP) is a little characterized protooncogene that has been implicated in the etiology of breast and thyroid tumors. In this study, we created a murine transgenic model to target PBF expression to the thyroid gland (PBF-Tg mice) and found that these mice exhibited normal thyroid function, but a striking enlargement of the thyroi...

Nowadays energy consumption problem is a major issue for data centers. The energy consumption increases significantly along with its CPU frequency getting higher. With Dynamic Voltage and Frequency Scaling (DVFS) techniques, CPU could be set to a suitable working frequency during the running time according to the workload. On the other side, reducing frequency implies that more servers will be ...

The PTTG1-binding factor (PBF/PTTG1IP) has an emerging repertoire of roles, especially in thyroid biology, and functions as a protooncogene. High PBF expression is independently associated with poor prognosis and lower disease-specific survival in human thyroid cancer. However, the precise role of PBF in thyroid tumorigenesis is unclear. Here, we present extensive evidence demonstrating that PB...

Ewing's sarcoma family of tumors (ESFT) is comprised of highly malignant bone and soft tissue tumors in children and young adults. Despite intensive treatments for patients with ESFT, disease which presents with metastatic spread or relapses after primary treatment remains incurable in the majority of cases, indicating the importance of efforts to develop new treatment modalities, including imm...

Differentiated thyroid cancers and their metastases frequently exhibit reduced iodide uptake, impacting on the efficacy of radioiodine ablation therapy. PTTG binding factor (PBF) is a proto-oncogene implicated in the pathogenesis of thyroid cancer. We recently reported that PBF inhibits iodide uptake, and have now elucidated a mechanism by which PBF directly modulates sodium iodide symporter (N...

Pituitary tumor-transforming gene 1-binding factor (PTTG1IP; PBF) is a multifunctional glycoprotein, which is overexpressed in a wide range of tumours, and significantly associated with poorer oncological outcomes, such as early tumour recurrence, distant metastasis, extramural vascular invasion and decreased disease-specific survival. PBF transforms NIH 3T3 fibroblasts and induces tumours in n...

A precursor-based approach to the cubic β-phase of PbF(2) was developed and allowed the preparation of this high-temperature phase well below the temperature for transition from the orthorhombic α- to the cubic β-phase. The formation of β-PbF(2) from the molecular precursors Pb[Se(C(6)H(2)(CF(3))(3))](2) and Pb(C(6)H(2)(CF(3))(3))(2) is facilitated by the presence of several short PbF contacts ...

The World Bank, through a grant from the Government of Norway, has launched several PBF initiatives in developing countries, systematically accompanied with an impact evaluation strategy using different innovative research designs.11 These initiatives should include formative research to address the rapidly changing social and political context that may influence policy implementation.12 The de...

BACKGROUND Current evidence suggests that in children there is a significant, albeit weak, association between asthma and obesity. Studies generally use body mass index (BMI) in evaluating body adiposity, but there are limitations to its use. METHOD Children from a population-based study attending follow-up (age 11 years) were weighed, measured and had percent body (PBF) and truncal (PTF) fat...

STUDY OBJECTIVES To assess the respective effects of position and positive end-expiratory pressure (PEEP) on the distribution of regional pulmonary blood flow (PBF). DESIGN Prospective randomized animal study. SETTING Animal research facility in a university hospital. PARTICIPANTS Normal pigs that were tracheostomized, anesthetized, and mechanically ventilated. INTERVENTIONS PBF was mea...