We report on the production experience of the DØ experiment at the Fermilab Tevatron, using the SAM data handling system with a variety of computing hardware configurations, batch systems, and mass storage strategies. We have stored more than 300 TB of data in the Fermilab Enstore mass storage system. We deliver data through this system at an average rate of more than 2 TB/day to analysis progr...

Plant lectins have attracted much attention for biomedical applications including targeted drug delivery system and therapy against tumors and microbial infections. The main problem of using lectins as a biomedical tool is a batch-to-batch variation in isoforms content. The production of lectins using recombination tools has the advantage of obtaining high amounts of proteins with more precise ...

The desired bioavailability and the method of drug administration and delivery can require stringent control on the crystal size distribution. Optimal control strategies are proposed to manufacture crystals with a targeted size distribution by combining controlled seeding by impinging jet crystallization with a batch crystallizer operating at a controlled constant growth rate. The same strategi...

In yard-crane scheduling problems, as loading operations take priority over unloading, the delivery sequence of unloading from quaysides to yard is uncertain. The changes may make crane more difficult. As a result, schedules developed statically become suboptimal or even infeasible. this paper, we propose dynamic problem considering uncertain sequences. A mixed-integer linear program assign tas...

Department of Pharmaceutics, Department of Phytopharmacy and Pharmacognosy, JSS College of Pharmacy, Udhagamandalam-643001, Tamil Nadu, India Abstract The objective of present work was to prepare a dual release drug delivery systems comprising fast and delayed release pattern using solid dispersion and pellets of the aceclofenac to achieve a desired in vitro and in vivo profile. Aceclofenac sol...

BACKGROUND RNA interference (RNAi) is a specific and effective approach for inhibiting viral replication by introducing double-stranded (ds)RNA targeting the viral gene. In this study, we employed a combinatorial approach to interfere multiple gene functions of white spot syndrome virus (WSSV), the most lethal shrimp virus, using a single-batch of dsRNA, so-called "multi-WSSV dsRNA." A co-culti...

Gold nanoparticles (AuNPs) can be used as delivery vehicles for platinum anticancer drugs, improving their targeting and uptake into cells. Here, we examine the appropriateness of different-sized AuNPs as components of platinum-based drug-delivery systems, investigating their controlled synthesis, reproducibility, consistency of drug loading, and stability. The active component of cisplatin was...

Nasal route had shown better systemic bioavailability due to its large surface area, porous endothelial membrane, high total blood flow, and avoidance of first-pass metabolism. Timolol maleate is a beta blocker used primarily in the treatment of hypertension. Drug undergoes extensive hepatic first-pass metabolism (80%). The drug has half-life of 4 hrs. Oral bioavailability of timolol maleate is...

The development of external stimulus-responsive nanoparticle (NP) systems for cancer therapy has received considerable attention in recent years, as these systems can differentially increase drug accumulation at target cancer cells/tissues, drastically decrease systemic toxicity, and potentially avoid underor over-dosing. External stimuli that have been exploited for such applications include l...