: World population has been continuously raised and therefore due to this fact new source of foods, particularly proteins, are in demand. In recent years, single cell protein has been considered as an accepted substitute for animal and plant proteins. In this study, single cell protein production was studied in a batch submerged culture using Aspergillus niger PTCC5012. Experimental design was ...

Introduction A perfusion-based process was developed to increase the split ratio during the scale-up of CHO-STM cell cultures. Fedbatch cultures were inoculated with cells propagated in either batch or perfusion cultures. All cultures were grown in disposable CellbagTM bioreactors using the WAVE Bioreactor system. Cell concentrations of 4.8 × 10 cells/mL were achieved in the perfusion culture, ...

Introduction A perfusion-based process was developed to increase the split ratio during the scale-up of CHO-STM cell cultures. Fedbatch cultures were inoculated with cells propagated in either batch or perfusion cultures. All cultures were grown in disposable CellbagTM bioreactors using the WAVE Bioreactor system. Cell concentrations of 4.8 × 10 cells/mL were achieved in the perfusion culture, ...

The membrane fouling of an aerobic granular reactor coupled with a submerged membrane in a sequencing batch reactor (SBR) was evaluated. The fouling analysis was performed by applying microscopy techniques to determine the morphology and structure of the fouling layer on a polyvinylidene fluoride membrane. It was found that the main cause of fouling was the polysaccharide adsorption on the memb...

A published mathematical model for growth of pellets of filamentous microorganisms has been tested by comparison of model predictions with experimental data on growth of Streptomyces coelicolor in liquid batch culture. The original model considered the classification of pellets into a range of size classes. Growth resulted in movement of pellets to classes of increasing size, while shear forces...

The rates of ethylene production per unit mass of Mucor hiemalis are highest at low specific growth rates. Thus this fungus probably produces more ethylene in the soil, where growth rates are low, than would have been predicted by laboratory batch culture, where growth rates are high. The rate of utilization of energyyielding substrate by Mucor hiemalisincreases logarithmically with growth rate...

In this study, urease production was investigated among thirteen strains of Aspergillus niger seven strains isolated from soils of Semnan province in Iran and six strains obtained from Persian Type Culture Collection (PTCC). The enzyme production was screened in two submerged media quantitatively. The registered PTCC 5011 and the native S31 strains showed more urease production than the other e...

Studying evolution in the laboratory provides a means of understanding the processes, dynamics and outcomes of adaptive evolution in precisely controlled and readily replicated conditions. The advantages of experimental evolution are maximized when the selection is well defined, which enables linking genotype, phenotype and fitness. One means of maintaining a defined selection is continuous cul...