Bax is cleaved by calpain at aspartate 33 (Asp33) to yield p18 Bax during stress-induced apoptosis. To assess the role of p18 Bax in apoptosis, an ecdysone-inducible expression system was generated. Similar levels of wild-type (WT) and noncleavable Asp33Ala (Asp-->Ala) Bax are induced in 293 cells while expression of N-terminal-deleted p18 (Delta1-33) Bax remains low (20% of full-length p21 Bax...

Introduction: Although the initial hypothesis for the action of doxepin was based on the inhibition of the reuptake of neurotransmitters, it has been suggested that it may also involve other mechanisms. Therefore, this study aims to investigate the effect of doxepin on spatial memory, tumor necrosis factor alpha (TNF-&alpha) level, expression of pro-apoptotic (Bad and Bax) and anti-apoptotic (B...

Breast cancer is the most common type of amongst women. Apoptosis known as a programmed cell death and this mechanism induces death. Dihydropyrrole compounds contain heterocyclic structure these molecules have many biological effects including functioning antioxidants anticancer molecules. In regard, aim research was to investigate how PhTAD-substituted dihydropyrrole affect expression apoptoti...

Background: Cancer treatment methods can lead to male infertility .in this regard, cryopreservation of spermatogonial stem cells (SSC) and cell-to-person transplantation after the course of treatment to resolve the problem of infertility is a good one. The cryopreservation of SSC is an important process as it can help on the return of spermatogenesis. However, during this process, the stem cell...

introduction: the amount of expression of bax and bcl-2 genes in infertile men’s sperm as well as its association with sperm parameters and dna fragmentation index is an issue which has not been studied yet. in this research, it is assumed that up-regulation of bax and downregulation of bcl-2 are directly associated with sperm dna fragmentation. methods: after obtaining semen samples from the p...

background:   materials and methods: this was a cross-sectional study carried out among 70 samples, including 10 samples from normal healthy mucosa categorized into group 1, group 2 (30 olp), and group 3 (30 oed) samples. five sections (4 μm thick) were obtained and stained with monoclonal antibodies such as ki-67, p53, bcl-2, and bax and analyzed for number of positive cells and also for inten...