The detection of Bence Jones protein, an important part of the investigation of suspected myeloma, is most commonly done by agarose or cellulose nitrate electrophoresis followed by immunofixation. Bence Jones protein is recognized as single or multiple bands of one type of light chain. Unfortunately, improvements in sensitivity of these techniques (use of high-affinity antisera and higher resol...

A method has been developed for fragmenting immunoglobulin light and heavy polypeptide chains at the cysteinyl residues that participate in intrachain disulfide bridges. The method involves the quantitative blockage of positive charges associated with lysyl and arginyl residues, the reduction and subsequent aminoethylation of disulfide bridges, and the treatment of aminoethylated, blocked chain...

We investigate when Isomorphism Conjectures, such as the ones due to Baum-Connes, Bost and Farrell-Jones, are stable under colimits of groups over directed sets (with not necessarily injective structure maps). We show in particular that both the K-theoretic Farrell-Jones Conjecture and the Bost Conjecture with coefficients hold for those groups for which Higson, Lafforgue and Skandalis have dis...

The name Bence Jones is recognized today as the name of a protein excreted by patients with multiple myeloma. It is ironic that Bence Jones was not the first to describe the characteristics of the protein, but he recognized its place in the diagnosis of myeloma when he wrote, `I need hardly remark on the importance of seeking for this oxide of albumen in other cases of mollities ossium' (Bence ...

We present a systematic study of the thermodynamics of two and three-dimensional generalized Lennard-Jones (LJ) systems focusing on the relationship between the range of the potential, the system density and its dimension. We found that the existence of negative specific heats depends on these three factors and not only on the potential range and the density of the system as stated in recent co...

The frequent occurrence of protein anomalies in patients with myelomatosis has long been recognized. Bence Jones reported on the unusual urinary protein of a patient with this disease over a hundred years ago (Bence Jones, 1848). Hyperproteinaemia in myelomatosis was recorded somewhat later (Ellinger, 1899). Subsequently, electrophoretic studies have shown that the hyperproteinaemia is due to t...

A patient with lambda Bence-Jones proteinuria, Waldenström's macroglobulinaemia, and Franklin's disease (gamma HCD), but without clinical evidence of a lymphoproliferative disorder, is presented. The serum contained two distinct immunoglobulin abnormalities: a monoclonal immunoglobulin M (IgM) of lambda type, and a protein fragment which was immunologically related to immunoglobulin G (IgG) and...

We study the role of the attractive intermolecular forces in the viscous regime of a simple glass-forming liquid by using computer simulations. To this end, we compare the structure and the dynamics of a standard Lennard-Jones glass-forming liquid model with and without the attractive tail of the interaction potentials. The viscous slowing down of the two systems is found to be quantitatively a...