نتایج جستجو برای: benzoapyrene bap

تعداد نتایج: 3093  

Journal: :Journal of cardiovascular pharmacology 2011
Mona E Aboutabl Beshay N M Zordoky Bruce D Hammock Ayman O S El-Kadi

We recently demonstrated that benzo(a)pyrene (BaP) causes cardiac hypertrophy by altering arachidonic acid metabolism through the induction of the expression of CYP ω-hydroxylases and soluble epoxide hydrolase (sEH) enzymes. The inhibition of CYP ω-hydroxylase enzymes partially reversed the BaP-induced cardiac hypertrophy. Therefore, it is important to examine whether the inhibition of sEH also...

Journal: :Pakistan journal of biological sciences : PJBS 2008
V G Omran A Bagheri N Moshtaghi

This study surveyed a rapid, efficient and reproducible protocol for in vitro shoot regeneration and rooting by different explants and different concentration of BAP. Due to optimization of shoot regeneration, two media including of MS and modified MS (MS salts with double concentration of CaC21, and B5 vitamins), different explants such as decapitated embryo axes, epicotyls and cotyledonary no...

Journal: :Vascular Health and Risk Management 2008
Yong Zhang Kenneth S Ramos

Cigarette smoking has been strongly associated with abdominal aortic aneurysm (AAA), but the components of tobacco smoke involved in AAA have not been identified. Benzo(a)pyrene (BaP) is an important constituent in cigarette smoke capable of induction of alterations strikingly similar to the pathological changes seen during AAA development. We therefore hypothesized that BaP exposure contribute...

2016
Samira Eslamizad Farzad Kobarfard Katayon Javidnia Ramezan Sadeghi Mitra Bayat Sara Shahanipour Najmeh Khalighian Hassan Yazdanpanah

A fast and simple modified QuEChERS extraction method was developed for determination of Benzo[a]pyrene (BaP) in 137 traditional (Sangak), semi-industrial (Sangak) and industrial bread samples using spiked calibration curves by GC/MS. Sample preparation includes extraction of BaP into acetone followed by cleanup with dispersive solid phase extraction. The limit of detection and limit of quantif...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2012
Chengzhi Chen Yan Tang Xuejun Jiang Youbin Qi Shuqun Cheng Chongying Qiu Bin Peng Baijie Tu

Previous studies have demonstrated that benzo(a)pyrene (BaP) may disrupt the development of key biological systems, thus leaving children more vulnerable to functional impairments in adulthood. The current study was conducted to determine whether neurotoxic effects of postnatal BaP exposure on behavioral performance persist in juvenile and young adult stages. Therefore, neonate Sprague-Dawley p...

2012
Jaione Valle Cristina Latasa Carmen Gil Alejandro Toledo-Arana Cristina Solano José R. Penadés Iñigo Lasa

The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, little is known about its responsibility in the interaction of biofilm cells with host tissues. Staphylococcus aureus, a leading cause of biofilm-associated chronic infections, ...

Journal: :Cancer research 1988
K Alexandrov M Sala M Rojas

Benzo(a)pyrene (BaP) is highly carcinogenic in rats but is without effect in rabbits when administered s.c. The possibility that BaP-DNA adducts could be responsible for this species difference was investigated by comparing BaP-deoxyribonucleoside adducts formed in dermal fibroblast cultures from Wistar rats and New Zealand rabbits. Treatment with [G-3H]BaP (1.2 microM) for 6, 24, and 48 h prod...

Journal: :Journal of analytical toxicology 2008
Angela D Ragin Kenroy E Crawford Alisha A Etheredge James Grainger Donald G Patterson

We developed a gas chromatography-isotope dilution high-resolution mass spectrometry (GC-ID-HRMS) method for quantifying isomers of benzo[a]pyrene (BaP) tetrol metabolites resulting from hydrolysis of benzo[a]pyrene-diol-epoxide hemoglobin (BaPDE-Hb) adducts. Acid hydrolysis of BPDE-Hb adducts extracted from human blood samples yielded isomers of benzo[a]pyrene-tetrahydrotetrols, (+/-)-BaP-r-7,...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2012
Manabu Matsunawa Daisuke Akagi Shigeyuki Uno Kaori Endo-Umeda Sachiko Yamada Kazumasa Ikeda Makoto Makishima

Benzo[a]pyrene (BaP) activates the aryl hydrocarbon (AHR) and induces the expression of genes involved in xenobiotic metabolism, including CYP1A1. CYP1A1 is involved not only in BaP detoxification but also in metabolic activation, which results in DNA adduct formation. Vitamin D receptor (VDR) belongs to the NR1I subfamily of the nuclear receptor superfamily, which also regulates expression of ...

2011
Hyo Jin Kang Young Bin Hong Hee Jeong Kim Olga C. Rodriguez Raghu G. Nath Elena M. Tilli Christopher Albanese Fung-Lung Chung Sang Hoon Kwon Insoo Bae

Our studies found that BRCA1 levels negatively correlate with DNA adducts induced by Benzo(a)pyrene (BaP). Pulse-chase experiments showed that the increase in BaP-induced DNA adducts in BRCA1 knockdown cells may not be associated with BRCA1's function in nucleotide excision repair activity; rather, it may be associated with its function in modulating transcriptional regulation. BRCA1 knockdown ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید