This study describes the synthesis, photophysical characterization, and TD-DFT calculation of a series benzothiazole-based styryl fluorophores (F1-F5) harboring D-π-A structure. The compounds were obtained through simple efficient synthetic route using low-cost starting materials. investigation analysis their properties enable assessment effect four substituted benzothiazole moieties (A) two ty...

Cd(II) complexes of 2-substituted benzothiazole derivatives have been synthesized. The structural features have been determined from their microanalytical, magnetic susceptibility, IR, H NMR spectral data. All the Cd(II) complexes exhibit the composition [Cd(L-L)(A-A)] where L-L HPBT, MPBT and A-A, Leucine, Isoleucine, Valine. The N, O, S donor ligands and Amino acids act as a bidentate ligands...

Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles possess potent antiproliferative activity against certain cancer cells, similar to the unfluorinated 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495). In "sensitive" cancer cells, DF 203 is metabolized by, can induce expression of, and binds covalently to CYP1A1. Metabolism appears to be essential for its antiproliferative activit...

Agonists induce Ca2+ spikes, waves and oscillations initiating at a trigger zone in exocrine acinar cells via Ca2+ release from intracellular Ca2+ stores. Using a low affinity ratiometric Ca2+ indicator dye, benzothiazole coumarin (BTC), we found that high concentrations of agonists transiently increased Ca2+ concentrations to the micromolar range (>10 microM) in the trigger zone. Comparison wi...

A series of 2-(benzo[d]thiazol-2-ylthio)-N-(2-oxoindolin-3-ylidene)acetohydrazide (3a3g), 2-(benzo [d]thiazol-2-ylthio)-N-(2,4’-dioxospiro[indolin-3,2’-thiazolidin)-3’yl)acetamide (4a-4g) and 2'-((benzo[d]thiazol-2-ylthio)methyl)spiro[indoline-3,5'thiazolo[4,3-b][1,3,4]oxadiazol]-2-ones (5a-5g) have been synthesized and screened for their anti-inflammatory, analgesic and antibacterial activitie...