Human chorionic gonadotropin (hCG) is used for treatment of pregnant women with threatened and repeated miscarriages/spontaneous abortions in Hungary. Thus the objective of the study was to evaluate the possible association of medically recorded hCG treatment during the second and/or third gestational month in pregnant women with the risk of different congenital abnormalities in their offspring...

HCG is composed of two subunits, HCGalpha and HCGbeta. During early pregnancy, HCG stimulates progesterone production in the corpus luteum, and injection of HCG is widely used to induce ovulation in assisted reproduction treatment (ART). Under experimental conditions, the free subunits have been shown to exert functions other than those of HCG, but the relevance of these remains to be determine...

The amino acid sequences of both the alpha and beta subunits of human chorionic gonadotropin have been determined. The amino acid sequence of the alpha subunit is: Ala - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys-10 - Thr - Leu - Gln - Asp - Pro - Phe - Ser - Gln-20 - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly-30 - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro-40 -...

Background: Spontaneous ovarian hyperstimulation syndrome rarely occurs during pregnancy and is usually associated with high levels of human chorionic gonadotropin, in conditions such as molar or multifetal pregnancies. Case report: Here we report spontaneous ovarian hyperstimulation in a patient presenting with missed abortion at 16th week of gestation, when serum ß-subunit human chorionic gon...

Immunohistological methods were used to investigate the presence of carcinoembryonic antigen, beta 1 pregnancy specific glycoprotein, beta subunit of human chorionic gonadotrophin, human placental lactogen, calcitonin, and keratin in formalin fixed tissue from 29 malignant mesotheliomas and 27 pulmonary adenocarcinomas. Malignant mesotheliomas were negative for tumour markers except for the bet...

The synthesis and secretion of human chorionic gonadotropin (hCG) subunits have been studied by pulse-chase techniques in JAR choriocarcinoma cells, which produce both the alpha and beta subunits of hCG "eutopically," that is, as part of their expected repertoire of gene products, and in three cell lines that produce either alpha or beta subunit "ectopically." JAR cells contain two intracellula...

many findings point to the presence of a close relationship between the immune, endocrine and neurologic systems. for example the suppressive effects of β-human chorionic gonadotropin (β-hcg) on il-l production, the potentiative effect of enkephalins on lymphocyte functions and the suppressive effect of leuteinizing hormone (lh) on natural killer (nk) cell activities have been clearly establish...

Human chorionic gonadotropin has been used for decades, in addition to specific investigations, to detect pregnancy, trophoblastic tumors, as well as congenital defects. Rarely, it can be elevated in  non-trophoblastic tumors such as squamous cell cancers and germ cell tumors. A 33-year-old Asian Syrian female had irregular menses accompanied with feelings of heaviness in the vagina. In additio...