The objective of this study was to investigate whether corticosteroids modulate neuropathic pain by altering cerebral expression of nuclear factor-kappa B (NF-kappaB) and specific cytokines. The effects of topical betamethasone on neuropathic pain and cerebral expression of NF-kappaB and cytokines were studied in a rat model of L5 spinal nerve transaction. Behavioral testing was undertaken on d...

Background: Betamethasone treatment is widely used and recommended worldwide. Although, there are no enough studies to look for the risk or potential alterations due accumulation of this drug before fertilization. In addition, previous payed attention intramuscular injection during pregnancy neglecting long-term impact use topical solutions. So, aim present study was determine side effect. Meth...

Background: Lichen planus is a common dermatological condition. Many treatment options have been discussed in literature, each with its own risk profile. Betamethasone pulse therapy is one of the effective therapies mentioned.The objective of this study was to find out whether oral betamethasone mini pulse therapy is effective in lichen planus.Methods: A total of 40 pat...

INTRODUCTION Calcium hydroxide (CH) is one of the most common intracanal medications. Corticosteroids (CS) are used in endodontics because of their anti-inflammatory activity. This study aimed to evaluate the antimicrobial effect of CH+betamethasone and CH+saline against Enterococcus faecalis (E. faecalis) using agar diffusion test and measuring the microbial zone of inhibition (ZOI). METHODS...

Exposure to clinically relevant doses of glucocorticoids during fetal life increases blood pressure in adult male and female sheep. The purpose of this study was to evaluate the effects of prenatal exposure to betamethasone at 80-81 days of gestation on renal function in ewes and rams at 1.5 yr of age. In prenatal betamethasone-exposed males, compared with the vehicle-exposed animals, basal glo...

Betamethasone is a synthetic corticosteroid designed to exert a marked glucocorticoid activity. As the free alcohol, betamethasone finds widespread clinical applications related to its anti-inflammatory and immunosuppressant activity. In the present study, a fast, sensitive, robust method was developed for the determination and quantification of betamethasone in human plasma by liquid chromatog...

BACKGROUND Various systemic agents have been assessed for the treatment of alopecia areata (AA); however, there is a paucity of comparative studies. OBJECTIVE To assess and compare cyclosporine and betamethasone minipulse therapy as treatments for AA with regard to effectiveness and safety. METHODS Data were collected from 88 patients who received at least 3 months of oral cyclosporine (n=5...

sterone or [16B-”H]betamethasone was given at a dose of 0.23pmol/kg body wt. by intraperitoneal or intravenous route, and bile samples were collected at 30min intervals. In some experiments the animals were pretreated with daily doses (100mg/kg body wt., intraperitoneally) of phenobarbital for 3 consecutive days. In the isolated-liver perfusion experiments tissue-culture medium 199 (100ml) cont...

introduction: postoperative sore throat is a common complaint in patients with endotracheal intubation and has potentially dangerous complications. this randomized controlled trial study investigated the incidence of postoperative sore throat after general anesthesia when betamethasone gel is applied to a tracheal tube compared with when iv dexamethasone is prescribed.   materials and methods: ...

Intranasal betamethasone sodium phosphate drops (Betnesol) are frequently used to relieve nasal congestion due to polyposis. We report a case of significant hypothalamic-pituitary-adrenal suppression secondary to the long-term use of intranasal betamethasone drops. This case emphasizes that the topical application of potent corticosteroids may produce systemic effects.