Purpose: To determine the inhibitory potential of betulinic acid on pro-survival signaling pathway in glioblastoma.Methods: Changes viabilities glioma cells and primary astrocytes were measured using 3-(4, 5dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Apoptotic changes analyzed Hoechst 33342 staining Annexin V-FITC/PI kits. Western blotting was used for assaying protein e...

A series of new imidazole carboxylic esters (carbamates) and N-acylimidazole derivatives of betulin and betulinic acid (14-29) have been synthesized. The new compounds were screened for in vitro cytotoxicity activity against human cancer cell lines HepG2, Jurkat and HeLa. A number of compounds have shown IC(50) values lower than 2 microM against the cancer cell lines tested and the vast majorit...

Background and objectives: Betulinic acid (BA), oleanolic acid (OA) and ursolic acid (UA) are well-known pentacyclic triterpenoids (PTs), which are produced by plants. They possess a variety of beneficial effects including anti-inflammatory, hepatoprotective, antitumor, anti-HIV, antimicrobial, gastroprotective, and antihyperlipidemic activities. In the present study, quantitative determination...

The title compound [systematic name: 3β-hy-droxy-lup-20(29)-en-28-oic acid methanol monosolvate], C30H48O3·CH3OH, is a solvent pseudopolymorph of a naturally occurring plant-derived lupane-type penta-cyclic triterpenoid, which was isolated from the traditional Chinese medicinal plant Syzygium jambos (L.) Alston. The dihedral angle between the planes of the carb-oxy-lic acid group and the olefin...