Bicaudal-D (Bic-D) is essential for the establishment of oocyte fate and subsequently for polarity formation within the developing Drosophila oocyte. To find out where in the germ cells Bic-D performs its various functions we made transgenic flies expressing a chimeric Bic-D::GFP fusion protein. Once Bic-D::GFP preferentially accumulates in the oocyte, it shows an initial anterior localization ...

Abstract During the last 20 years, there has been an increased interest among academics and practitioners in area of business incubation. However, limited attention devoted to developing a comprehensive framework that can measure incubators' performances. Therefore, is urgent need for appropriate, robust useable performance framework. In this paper, we present using weighted fuzzy inference sys...

BACKGROUND The influences of potential bone-to-implant contact (BIC) area (pBICA), BIC area (BICA), and three dimensional (3D) BIC percentage (3D BIC%; defined as BICA divided by pBICA) in relation to the implant length on initial implant stability were studied. Correlations between these parameters were also evaluated. METHODS Implants with lengths of 8.5, 10, 11.5, and 13 mm were placed in ...

In the last two years, COVID-19 had claimed millions of life in Nigeria and world at large. It is an established global health emergency our time ongoing threat faced by up till now. This study aims to determine trend, fit appropriate Error Trend Seasonal (ETS) exponential smoothing ARIMA model daily deaths Nigeria. Dataset on confirmed death cases were utilized study. The data was extracted fr...

We study BIC-like model selection criteria. In particular, we approximate the lower-order terms, which typically include the constant log ∫ √ det I(θ) dθ, where I(θ) is the Fisher information at parameter value θ. We observe that the constant can sometimes be a huge negative number that dominates the other terms in the criterion for moderate sample sizes. At least in the case of Markov sources,...

We apply the nonconcave penalized likelihood approach to obtain variable selections as well as shrinkage estimators. This approach relies heavily on the choice of regularization parameter, which controls the model complexity. In this paper, we propose employing the generalized information criterion (GIC), encompassing the commonly used Akaike information criterion (AIC) and Bayesian information...

Bictegravir (BIC; GS-9883), a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase (IN), specifically targets IN strand transfer activity (50% inhibitory concentration [IC50] of 7.5 ± 0.3 nM) and HIV-1 integration in cells. BIC exhibits potent and selective in vitro antiretroviral activity in both T-cell lines and primary human T lymphocytes, with 50% effective concentrations rangi...

Cytochrome P450 46A1 (CYP46A1) is the cholesterol 24-hydroxylase initiating the major pathways of cholesterol removal from the brain, and bicalutamide (BIC) is a drug of choice for the treatment of progressive androgen-dependent prostate cancer. We evaluated the interactions of BIC with CYP46A1 by x-ray crystallography and by conducting solution and mutagenesis studies. Because BIC is administe...

We previously demonstrated high expression of primary-microRNA BIC (pri-miR-155) in Hodgkin lymphoma (HL) and lack of expression in most non-Hodgkin lymphoma subtypes including some Burkitt lymphoma (BL) cases. Recently, high expression of BIC was reported in BL in comparison to pediatric leukemia and normal peripheral-blood samples. In this study, we extended our series of BL cases and cell li...

In this paper, we propose a clustering method by SOM and information criteria. In this method, initial cluster-candidates are derived by SOM, and then these candidates are merged appropriately based on information criterion such as BIC or AIC (Akaike Information Criterion). Through the clustering experiments for the artificial datasets and UCI Machine Learning Repository’s datasets, we confirm ...