An apparatus is reported for real-time Raman monitoring of reactions performed using continuous-flow processing. Its capability is assessed by studying four reactions, all involving formation of products bearing α,β-unsaturated carbonyl moieties; synthesis of 3-acetylcoumarin, Knoevenagel and Claisen-Schmidt condensations, and a Biginelli reaction. In each case it is possible to monitor the rea...

   This procedure has developed the use of TiO2 nanoparticles as an environmentally friendly and highly efficient heterogenous nanocatalyst for the eco-safe, facile and one-pot three-component Biginelli synthesis of biologically active corresponding 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives under solvent-free conditions. This eco-friendly protocol provi...

In this research, one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)-ones havebeen developed using Biginelli reaction from the interaction between ethyl/methyl acetoacetate,aromatic aldehydes, and urea/thiourea in the presence of 4-sulfobenzoic acid as a new, effective,inexpensive, and available bronsted acid. Avoidance of toxic and dangerous solvents, easy isola...

In this study, novel phthalonitrile 3 and their corresponding metal-free 4 and metallophthalocyanine derivatives 5-7 bearing 2-isopropenyl-4-methoxy-1-methylbenzene groups were synthesized and characterized. 3,4-Dihydropyrimidinones have been synthesized by a modified Biginelli-type reaction with various metallophthalocyanines 5-7 as catalysts. Compared to the classical Biginielli reaction, the...

In this research, a green, operationally simple, highly efficient and facile cascade Biginelli reaction using various aromatic aldehydes, ethyl acetoacetate, and urea/thiourea has been developed. First, the ionic liquid was prepared from the reaction of 1-methyl-2-pyrolidone with methane sulfonic acid. Then, this ionic liquid was applied as an acidic catalyst in the synthesis of dihydropyrimidi...

An efficient one-pot synthesis of 1,2,3-triazole derivatives of dihydropyrimidinones has been developed using two multicomponent reactions. The aldehyde-1,2,3-triazoles were obtained in good yields from in situ-generated organic azides and O-propargylbenzaldehyde. The target heterocycles were synthesized through the Biginelli reaction in which the aldehyde-1,2,3-triazoles reacted with ethyl ace...

3,4-dihydropyrimidin-2(1h)-thiones were synthesized in the presence of ag nanoparticle/melamine sulfonic acid (msa) supported on silica gel. the reaction was carried out at 110 oc for 20 min under solvent free conditions. in all cases, the three component reaction proceeded smoothly to give the corresponding 3,4-dihydropyrimidin-2(1h)-thiones in moderate to good yield. we have found the best co...