THE concept of an association between congenital syphilitic interstitial keratitis and the development of late glaucoma is not new. Hutchinson (1863) reported the case of a man aged 24 with congenital syphilis who had suffered bilateral interstitial keratitis at the age of 6; both eyes had deeply cupped and atrophic optic discs and iridectomy failed to control the glaucoma. Hutchinson believed ...

Bacterial keratitis is a sight-threatening corneal disease that is most commonly associated with the extended wear of soft contact lenses. Over the past decade, we have investigated the pathogenesis of infectious keratitis involving the opportunistic pathogen Pseudomonas aeruginosa. Our research has focused on understanding the respective roles of bacteria and host in the establishment of this ...

Müller et al. studied corneal nerve morphology and endothelial cell density (ECD) in patients with and without unilateral herpes simplex keratitis (HSK). They demonstrated correlated reductions in corneal central ECD, subbasal nerve number and length, and sensation in both the affected and clinically unaffected contralateral eyes. They suggest a potential link between corneal innervation and en...

Purpose: Systemic doxycycline has been prescribed to reduce inflammation and enhance corneal healing in bacterial keratitis. Topical autologous serum drops (ASD) containing following oral supplementation may additionally confer an anti-bacterial effect. The potential of this was evaluated by determining the vitro susceptibility keratitis isolates doxycycline. Methods: minimum inhibitory concent...

PURPOSE To characterize the clinical features and therapeutic outcome of Candida keratitis. DESIGN Retrospective, observational case series. METHODS We reviewed 26 patients treated for Candida keratitis, including two with recurrent keratitis and one with bilateral infection. RESULTS Of 29 keratitis episodes resulting from Candida albicans (n = 20) or Candida parapsilosis (n = 9), 16 (55%...

Bacterial keratitis can cause significant morbidity from ulceration of the cornea and the resultant scarring. The use of steroids to decrease these complications is controversial with arguments for and against their use. The SCUT (Steroids for Corneal Ulcers Trial) was initiated in 2006 to definitively determine whether steroids in bacterial keratitis were beneficial or harmful. While the SCUT ...

Aim: To assess whether the presence of characteristic clinical features can be used as a diagnostic aid for suppurative keratitis caused by filamentous fungi. Methods: Patients presenting with suppurative keratitis in India underwent detailed clinical examination followed by microbiological investigation of corneal scrapes. A partial diagnostic score based upon the strength of the association, ...

AIM To assess whether the presence of characteristic clinical features can be used as a diagnostic aid for suppurative keratitis caused by filamentous fungi. METHODS Patients presenting with suppurative keratitis in India underwent detailed clinical examination followed by microbiological investigation of corneal scrapes. A partial diagnostic score based upon the strength of the association, ...