After adult liver transplantation (LT), post-transplant lymphoproliferative disorder (PTLD) is an uncommon but serious complication of immunosuppression (IMS) in presence of an acute or latent EBV infection. The clinical presentation of this disease is aspecific, and, after LT, it may mimic anastomotic bile duct stricture. We report the cases of 2 adult patients who developed, 3 months and 8 ye...

background : most diagnostic tests for biliary atresia (ba) are invasive. this study evaluates the sensitivity and specificity of serum  tumor necrosis factor-α (tnf-α) for diagnosing extra hepatic biliary duct atresia (ehba) in infants. materials and methods : infants with cholestasis who were admitted to children′s medical center hospital were evaluated. a total of 50 infants (20 with ehba an...

background liver cirrhosis is one of the major causes of hospitalization and mortality in children. a wide spectrum of disorders including developmental abnormali­ties, infections, metabolic and genetic disorders can lead to liver cirrhosis in pediatric patients. determination of its etiology is important for treatment mo­dality, prevention of progressive liver damage, family counseling and pri...

results hla-drb1*07 (rr 5.3, p = 0.0008) and hla-drb1*08 (rr n.c. p = 0.0005) were significantly associated with the risk of pbc development. patients younger than 45 years had significantly higher alanine aminotransferase (p = 0.038) and alkaline phosphatase levels (p = 0.047) than older cases. in comparison to non-cc rs12979860, patients with cc rs12979860 genotype showed an early histologica...

BACKGROUND Congenital absence of the gallbladder is a rare, usually asymptomatic, anatomical variation. Some affected individuals may present with a clinical picture suggestive of gallbladder disease. This presentation, coupled with the inability of standard abdominal ultrasonography to convincingly diagnose agenesis of the gallbladder, can put the surgeon in a diagnostic and intraoperative dil...

conclusions co-occurrence of pbc with wd is rare, which can cause diffusely intrahepatic copper deposition. early liver biopsy and genetic testing are necessary for the diagnosis. the combination of ursodeoxycholic acid with zinc and sodium dimercaptopropane sulfonate is effective. introduction both primary biliary cirrhosis (pbc) and wilson’s disease (wd) can cause copper retention in the live...

a 63-year-old woman suffering from progressive systemic sclerosis for about 20 years disclosed symptoms of liver disease within the last three years. diagnosis of biliary cirrhosis was established on the basis of clinical picture, pathological examination of the hepatic tissue sample, immunological tests, and x-ray studies. association of systemic sclerosis with primary biliary cirrhosis is bri...

astrointestinal bleeding from the biliary tree (hemobilia) s an uncommon event. Iatrogenic or traumatic liver injury re the most frequent causes of the disorder, accounting for ver 50% of cases, followed by gallstones, acalculous inflamation, vascular abnormalities and neoplastic disease [1]. are cases of spontaneous intracholecystic bleeding have een published in patients with vascular and coa...

Cystic fibrosis (CF) is the most common fatal autosomal recessive disorder in the white population with a frequency of 1 in 2500 live births. Inherited defects in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in abnormal regulation of salt and water movement across membranes. The overall feature of CF is that secretions are dehydrated due to water deprivation of lum...