After completing this article, readers should be able to: 1. List the risk factors for severe hyperbilirubinemia. 2. Distinguish between physiologic jaundice and pathologic jaundice of the newborn. 3. Recognize the clinical manifestations of acute bilirubin encephalopathy and the permanent clinical sequelae of kernicterus.4. Describe the evaluation of hyperbilirubinemia from birth through 3 mon...

Bilirubin is the end product of degradation of the heme moiety of hemoproteins. Hemoglobin, derived from senescent erythrocytes, is the major source of bilirubin. Significant fractions are also derived from other hemoproteins of liver and other organs. Historically, hyperbilirubinemia has attracted the attention of clinicians as a marker of liver dysfunction. Subsequently, the studies of biliru...

Introduction There is a growing concern about an increasing bilirubin-induced neurological dysfunction (BIND) in healthy term neonates with no evidence of hemolytic disease or other risk factors. This study was done to determine the incidence of BIND in otherwise healthy, breast-fed newborn term infants without hemolysis who underwent exchange transfusion. Materials and Methods This study was c...

Introduction Our recently published case reports and other healthy and highly educated patients of the long-term (28-42 years) follow-up suggest that D-Penicillamine (D-PA) therapy of newborn infants may have significant neuroprotective effects in cases jeopardized by bilirubin induced neurologic dysfunction (BIND) or retinopathy of prematurity (ROP) [1-3]. The first patient (43 ys) is now a me...

a. acute liver failure [III]; b. decompensated liver disease with ascites, encephalopathy (having excluded HIV-related dementia) or problematic varices and poor synthetic function, e.g. albumin o30 g/l, INR 41.5 and elevated serum bilirubin e.g. 450 mmol/L [III]; c. hepatocellular carcinoma (HCC) detected during regular tumour surveillance (recommended at least 6 monthly in all patients with ci...

Four years data from Special Care Baby Unit revealed neonatal jaundice (NNJ) as the commonest cause of hospitalization (1944 cases of NNJ out of 6454 admitted neonates). Majority (47.5%) of babies with NNJ presented between 4-7 days of birth. One hundred and sixty infants with NNJ were positive for Glucose 6 Phosphate dehydrogenase (G6PD) deficiency, of whom 153 were males and 7 females. Eighty...

INTRODUCTION Considering the prevalence of Jaundice in newborn infants and the risk of developing acute Bilirubin encephalopathy, in early weeks after birth. the importance of Infancy, as well as positive effects of giving massage on physical and behavioral growth and evolution of infants, the current study has been aimed to investigate the effects of Vimala massage on neonatal physiological Ja...